Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidney Transplantation: A Single Centre Experience

BioMed Research International
Maria Irene BelliniVassilios Papalois

Abstract

We present our experience with hypothermic machine perfusion (HMP) versus cold storage (CS) in relation to kidney transplant outcomes. Retrospective analysis of 33 consecutive HMP kidney transplant outcomes matched with those of 33 cold stored: delayed graft function (DGF), length of hospital stay (LOS), estimated glomerular filtration rate (eGFR), and patient and graft survival were compared. Renal Resistive Indexes (RIs) during HMP in relation to DGF were also analysed. In the HMP group, mean HMP time was 5.7 ± 3.9 hours with a mean cold ischaemic time (CIT) of 15 ± 5.6 versus 15.1 ± 5.3 hours in the CS group. DGF was lower in the HMP group (p=0.041), and donation after Circulatory Death (DCD) was a predictor for DGF (p<0.01). HMP decreased DGF in DCD grafts (p=0.036). Patient and graft survival were similar, but eGFR at 365 days was higher in the HMP cohort (p<0.001). RIs decreased during HMP (p<0.01); 2-hours RI ≥ 0.45 mmHg/mL/min predicted DGF in DCD kidneys (75% sensitivity, 80% specificity; area under the curve 0.78); 2-hours RI ≥ 0.2 mmHg/ml/min predicted DGF in DBD grafts (sensitivity 100%, specificity 91%; area under the curve 0.87). HMP decreased DGF compared to CS, offering viability assessment pretransplant and imp...Continue Reading

References

Jan 2, 2009·The New England Journal of Medicine·Cyril MoersRutger J Ploeg
Aug 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I JochmansJ Pirenne
Sep 21, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiedleckiD C Brennan
Aug 11, 2012·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Yuriy Y YushkovMichael J Goldstein
Oct 22, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Christophe LegendreFrank Martinez
Jan 30, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Ina JochmansRutger J Ploeg
Aug 19, 2015·Clinical and Experimental Pharmacology & Physiology·Osamu KuriharaWataru Shimizu
Oct 13, 2016·Journal of the American Society of Nephrology : JASN·Hessel Peters-SengersFrederike J Bemelman
Jan 6, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Charlotte von Horn, Thomas Minor
Apr 24, 2018·Current Opinion in Organ Transplantation·Alyssa WardJedediah K Lewis

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Citations

Sep 12, 2019·Journal of Clinical Medicine·Maria Irene BelliniVassilios Papalois
Jul 9, 2020·Journal of Clinical Medicine·Maria Irene BelliniJennifer A McCaughan
Aug 25, 2019·Journal of Clinical Medicine·Maria Irene BelliniVassilios Papalois
Sep 19, 2019·Journal of the Royal Society of Medicine·Greg Maguire
Jan 28, 2021·International Journal of Molecular Sciences·Maria Irene BelliniVito D'Andrea
Dec 14, 2019·Current Opinion in Organ Transplantation·Stephen O'Neill, Gabriel C Oniscu
Dec 9, 2020·Reproductive Biomedicine Online·Janice de Miranda Vasconcellos VilelaChristiani Andrade Amorim
May 14, 2021·Transplantation·Sarah A HosgoodMichael L Nicholson

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