PMID: 6405786Jun 10, 1983Paper

Cold stress induces in situ phospholipid molecular species changes in cell surface membranes

Biochimica Et Biophysica Acta
C S Ramesha, G A Thompson

Abstract

The structural organization of Tetrahymena pyriformis is such that its cilia are remote from the main centers of lipid metabolism. As a result, the ciliary membrane lipid composition of cells exposed to low-temperature stress is initially unaffected by the significant metabolic changes induced in microsomal membranes. Nevertheless, changes in the ciliary membrane lipid composition can be detected during the first 4 h of cold exposure. A combination of in vivo and in vitro experiments has provided strong evidence for a substantial retailoring of ciliary phospholipid molecular species in situ in the absence of any importation of lipids from the cell interior or change in overall ciliary fatty acid composition. The mechanism responsible for the ciliary lipid changes is independent of the one(s) triggering internal acclimation responses. Our observations establish for the first time that chilling stress can simultaneously induce separate and distinctive lipid modification responses in different parts of a cell. This finding could be important in identifying the molecular 'sensor' capable of actuating stress-induced lipid changes.

References

Jul 12, 1974·Biochimica Et Biophysica Acta·B De KruyffL L Van Deenen

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Citations

Feb 1, 1989·Journal of Bioenergetics and Biomembranes·G A Thompson
Nov 1, 1985·Molecular and Biochemical Parasitology·M C Connelly, F Kierszenbaum
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·J E BlyL W Clem
Jul 1, 1994·Insect Biochemistry and Molecular Biology·M M ShipleyJ R Sauer
Sep 1, 1997·Molecular and Biochemical Parasitology·M Florin-ChristensenL Rasmussen
Jan 1, 1993·Archives of Insect Biochemistry and Physiology·M M ShipleyJ R Sauer
Oct 1, 1985·Archives of Biochemistry and Biophysics·H A NormanG A Thompson
Mar 31, 1992·Biochemical and Biophysical Research Communications·M L AlessioC L Léger

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