Cold stress induces metabolic activation of thyrotrophin-releasing hormone-synthesising neurones in the magnocellular division of the hypothalamic paraventricular nucleus and concomitantly changes ovarian sympathetic activity parameters

Journal of Neuroendocrinology
J FiedlerS Arancibia

Abstract

Recent studies suggest thyrotrophin-releasing hormone (TRH) serves as a neurotransmitter and thereby provides a functional vegetative connection between the brain and the ovary. In the present study, magnocellular neurones of the paraventricular nucleus (PVN) in animals subjected to cold exposure were studied to determine the hypothalamic origin of the TRH involved in this pathway. In situ hybridisation analysis of hypothalamic tissue showed that cold exposure causes a two-fold increase in the total number of neurones expressing TRH mRNA in the PVN. Immunohistochemical studies showed that TRH peptide is localised to the magnocellular PVN and that the number of TRH immunoreactive cells increases two-fold following 64 h of cold exposure. Double-immunostaining for MAP-2 and TRH revealed that TRH peptide is localised in the perikarya of the magnocellular neurones. TRH release was measured in vivo from the magnocellular portion of the PVN using push-pull perfusion. Although controls exhibited a very low level of TRH release, animals subjected to cold showed a pulsatile-like TRH release profile with two different patterns of release: (i) low basal level with small bursts of TRH release and (ii) a profile with an up to seven-fold incr...Continue Reading

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Citations

Oct 16, 2010·Archives of Gynecology and Obstetrics·Farideh Zafari ZangenehMohammad Mahdi Naghizadeh
Jun 16, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B M NugentA H Paredes
May 9, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Rafael BarraHernán E Lara
Jan 27, 2009·Autonomic Neuroscience : Basic & Clinical·Daisuke UsuiKunihiko Yokotani
Nov 22, 2008·Fertility and Sterility·Evgenia IsachenkoJuergen M Weiss
Jul 22, 2014·Journal of Neuroendocrinology·D ToufexisV Viau
Jan 15, 2014·Stress : the International Journal on the Biology of Stress·Franz VeruSuzanne King
Oct 17, 2008·Biology of Reproduction·Mauricio DorfmanHernan E Lara
Apr 3, 2008·Brain, Behavior and Evolution·Laura DomínguezAgustín González
Mar 1, 2008·Endocrinology·Marcelo P BernuciJanete A Anselmo-Franci
Sep 5, 2020·Journal of Assisted Reproduction and Genetics·Janice de M V VilelaChristiani A Amorim
Apr 18, 2013·Physiological Research·A KozłowskaB Jana
Apr 16, 2020·Reproductive Biology and Endocrinology : RB&E·Di WangCairui Yang
Dec 1, 2020·Journal of Neuroendocrinology·Raul RiquelmeHernán E Lara
Oct 21, 2020·Cell Metabolism·Violeta HerasManuel Tena-Sempere
Dec 24, 2018·European Thyroid Journal·Zhi ZhangEric Fliers

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