Cold thoughts of death: the role of ICE proteases in neuronal cell death

Trends in Neurosciences
L M Schwartz, C E Milligan

Abstract

While there has been extensive work describing the timing, location and probable signals responsible for regulating programmed cell death (PCD) in the nervous system, relatively little is known about the molecular mechanisms that mediate this process. Several investigators have demonstrated that PCD in general, and neuronal PCD in particular, can be inhibited by drugs that arrest RNA or protein synthesis. These data have been interpreted as suggesting that de novo gene expression is required for cells to commit suicide. The general picture emerging from a number of experimental systems is that a variety of proteins can mediate the coupling of extracellular signals to a resident cell-death program. In this model, some of the components required for death are more or less constitutively present in the cell and await lineage-specific signals for their activation. A recent flood of papers has presented convincing evidence that the resident program for apoptosis in numerous cell types works via a series of essential proteases belonging to the CED-3/ICE family.

References

Dec 1, 1976·The Journal of Comparative Neurology·M Hollyday, V Hamburger
Apr 15, 1975·The Journal of Comparative Neurology·V Hamburger
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L RaoE White
Nov 1, 1991·Toxicology and Applied Pharmacology·D G RobertsonB Song
Dec 1, 1991·The Journal of Comparative Neurology·C E MilliganT J Cunningham
Jan 1, 1991·Annual Review of Cell Biology·R E EllisH R Horvitz
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L M SchwartzB K Kay
Mar 4, 1989·BMJ : British Medical Journal·M J Auger
Dec 1, 1985·Medical Hypotheses·W M Clouston, J F Kerr
Sep 21, 1984·Science·W M CowanB B Stanfield
Jan 1, 1982·International Review of Cytology·T J Cunningham
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Mar 10, 1995·Science·S Nagata, P Golstein
Mar 24, 1995·The Journal of Biological Chemistry·S J MartinD R Green
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y A LazebnikW C Earnshaw

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Citations

Aug 13, 1998·The Anatomical Record·J B Hutchins, S W Barger
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Apr 21, 1999·Brain Research. Brain Research Reviews·M WaltonM Dragunow
Apr 8, 1998·Trends in Neurosciences·B BecherJ P Antel
Dec 24, 1997·Brain Research. Molecular Brain Research·F GillardonK A Hossmann
Apr 2, 1999·Brain Research. Molecular Brain Research·P ChaudharyS C Sharma
Jun 6, 2003·Progress in Neurobiology·L Lossi, A Merighi
Oct 9, 1999·Progress in Neurobiology·E BrouilletP Hantraye
Apr 8, 1999·Early Human Development·A J Gunn, T R Gunn
Jan 13, 1998·Current Opinion in Biotechnology·R B Parekh, C Rohlff
Sep 1, 1997·Nature Medicine·D M Holtzman, M Deshmukh
Oct 26, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·X H LiuJ D Barks
Feb 25, 1998·Spine·I V SmirnovaB W Festoff
Jun 8, 2000·Annals of the New York Academy of Sciences·C Waters
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cristine Alves da CostaMarc P Mattson
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·V AvdoninL Iverson
Feb 23, 2000·Journal of Neuroimmunology·A AlcázarJ C Alvarez-Cermeño
Apr 27, 2011·Annals of Neurology·Frances J NorthingtonLee J Martin
Jul 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A N Miles, N W Knuckey
Jul 5, 2005·Expert Opinion on Investigational Drugs·L Denner
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·C J CookC D Devine
Oct 24, 1998·Experimental Neurology·B MontiA Contestabile
Jul 17, 1998·Vision Research·P D Koeberle, A K Ball
Jan 11, 2001·Neurosurgery·C J Hodge, M Boakye
Feb 16, 1999·Brain Pathology·M R Cookson, P J Shaw

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis