"Cold training" affects rat liver responses to continuous cold exposure

Free Radical Biology & Medicine
P VendittiS Di Meo

Abstract

Continuous exposure of homeothermic animals to low environmental temperatures elicits physiological adaptations necessary for animal survival, which are associated to higher generation of pro-oxidants in thermogenic tissues. It is not known whether intermittent cold exposure (cold training) is able to affect tissue responses to continuous cold exposure. Therefore, we investigated whether rat liver responses to continuous cold exposure of 2 days are modified by cold training (1h daily for 5 days per week for 3 consecutive weeks). Continuous cold increased liver oxidative metabolism by increasing tissue content of mitochondrial proteins and mitochondrial aerobic capacity. Cold training did not affect such parameters, but attenuated or prevented the changes elicited by continuous cold exposure. Two-day cold exposure increased lipid hydroperoxide and protein-bound carbonyl levels in homogenates and mitochondria, whereas cold training decreased such effects although it decreased only homogenate protein damage in control rats. The activities of the antioxidant enzymes GPX and GR and H2O2 production were increased by continuous cold exposure. Despite the increase in GPX and GR activities, livers from cold-exposed rats showed increased...Continue Reading

References

Nov 1, 1976·Analytical Biochemistry·R L Heath, A L Tappel
Jan 1, 1989·The Japanese Journal of Physiology·T Yahata, A Kuroshima
Mar 1, 1985·Archives of Biochemistry and Biophysics·J F TurrensA L Lehninger
Jul 1, 1996·Archives of Biochemistry and Biophysics·P Venditti, S Di Meo
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·D KnuttiA Kralli
Aug 2, 2003·Molecular and Cellular Endocrinology·Paola VendittiSergio Di Meo
Jun 1, 1960·Canadian Journal of Biochemistry and Physiology·O HEROUX
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·P VendittiS Di Meo
Aug 12, 2004·Free Radical Biology & Medicine·Martin D BrandNadeene Parker
Aug 17, 2010·The Journal of Experimental Biology·P VendittiS Di Meo
Apr 11, 2012·British Journal of Pharmacology·J VinaM C Gomez-Cabrera
Nov 22, 2013·Free Radical Research·P VendittiS Di Meo
Nov 23, 2013·The Journal of Experimental Biology·Antoine StierFrançois Criscuolo

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Citations

Feb 25, 2020·Journal of Animal Physiology and Animal Nutrition·Bin XuLi Zhen

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