Mar 1, 1986

Cold urticaria and virus infections: a clinical and serological study in 39 patients

The British Journal of Dermatology
H M DoeglasJ Schirm

Abstract

Thirty-nine patients with cold urticaria seen over a 12-year-period were re-examined. All but 12 still had positive skin tests for cold and only five of these had shown a spontaneous cure. Fourteen patients were prone to collapse on cold exposure. The incidence of atopy in this group was comparable to that in control groups. Cold urticaria is an extremely chronic disease. The mean disease duration was 9.3 years. Serum antibodies to Epstein-Barr virus, measles virus, cytomegalovirus (CMV), varicella-zoster virus (VZV), herpes simplex virus (HSV), Chlamydia psittaci and Mycoplasma pneumoniae were determined in all 39 patients and compared with control groups. The EBV-antibody patterns (heterophile antibodies and different types of EBV-specific antibodies) showed no evidence of current or of recent primary or secondary infection with EBV. Complement fixing antibody titres to measles virus, CMV, HSV and Mycoplasma pneumoniae were significantly higher in cold urticaria patients than in controls. The existence of a basic immuno-regulatory defect responsible for both the cold urticaria and the elevated antibody levels is proposed.

  • References11
  • Citations14
  • References11
  • Citations14

Citations

Mentioned in this Paper

Tumor Virus Infections
Chlamydia Infections
Cryopyrin-Associated Periodic Syndromes
Measles virus
Mycoplasma pneumoniae
Urticaria due to Cold
Antibodies, Viral
Virus Diseases
Cold Temperature
Simplexvirus

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

The British Journal of Dermatology
C N Matthews, R P Warin
The British Journal of Dermatology
R Y Lin, R A Schwartz
The Journal of Allergy and Clinical Immunology
A A Wanderer
The British Journal of Dermatology
A M Marsland, M H Beck
© 2020 Meta ULC. All rights reserved