Cold urticaria. Recognition and characterization of a neutrophil chemotactic factor which appears in serum during experimental cold challenge

The Journal of Clinical Investigation
S I WassermanK F Austen


Sera were obtained from the venous effluents of cold-challenged arms of patients with idiopathic cold urticaria without plasma or serum cryoproteins; these sera exhibited increased neutrophil chemotactic activity without alterations of the complement system. A two- to fourfold augmentation of the base-line neutrophil chemotactic activity of serum from the immersed extremity began within 1 min, peaked at 2 min, and returned to base-line levels within 15 min, whereas there was no change in the serum chemotactic activity in the control arm. The augmented chemotactic activity in the serum specimens from the challenged arm of each patient appeared in a high molecular-weight region, as assessed by the difference in activity recovered after Sephadex G-200 gel filtration of the paired lesional and control specimens. Sequential purification of this high molecular-weight activity by anion- and cation-exchange chromatography revealed a single peak of activity at both steps. The partially purified material continued to exhibit a high molecular weight, being excluded on Sepharose 4B, and had a neutral isoelectric point. The partially purified material showed a preferential chemotactic activity for neutrophilic polymorphonuclear leukocytes, ...Continue Reading


Jun 1, 1975·The Journal of Allergy and Clinical Immunology·A P KaplanM A Beaven
Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Jan 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·S I WassermanK F Austen
Oct 1, 1971·Annals of Internal Medicine·E J LewisP H Schur
Jul 1, 1973·The Journal of Allergy and Clinical Immunology·J DolovichJ Bienenstock
Dec 1, 1972·The Journal of Experimental Medicine·E J Goetzl, K F Austen
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Apr 1, 1968·The Journal of Experimental Medicine·P A Ward, E L Becker
Mar 1, 1954·The Journal of Allergy·B ROSE
Jan 1, 1963·The Journal of Allergy·G N BEALL
Sep 1, 1950·The Journal of Allergy·W B SHERMAN, P M SEEBOHM

❮ Previous
Next ❯


Jan 1, 1985·Archives of Dermatological Research·R K Winkelmann
Sep 1, 1983·Inflammation·S Wescott, M Kaliner
May 1, 1989·Digestive Diseases and Sciences·R A KozolS A Elgebaly
Jun 1, 1981·Springer Seminars in Immunopathology·B U Wintroub, N A Soter
Jan 1, 1984·Lung·E Bar-Yishay, S Godfrey
May 7, 2010·Current Allergy and Asthma Reports·Karoline KrauseMarcus Maurer
Feb 23, 1978·The New England Journal of Medicine·B U WintroubK F Austen
Mar 13, 1980·The New England Journal of Medicine·N A SoterE R McFadden
Oct 29, 1981·The New England Journal of Medicine·A P KaplanT Hauber
Mar 4, 1982·The New England Journal of Medicine·L NagyA B Kay
Aug 15, 1985·The New England Journal of Medicine·K E GrandelS I Wasserman
Jan 10, 1993·The New England Journal of Medicine·E R McFadden, I A Gilbert
Jan 1, 1986·Thorax·A D BlaineyR J Davies
Dec 1, 1987·The American Review of Respiratory Disease·D R BuchananA B Kay
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·D M CenterL Teran
Feb 1, 1978·The Journal of Clinical Investigation·R H StraussJ J Jaeger
Jul 1, 1979·The Journal of Clinical Investigation·J Fehr, C Dahinden
Mar 1, 1980·The Journal of Clinical Investigation·E C DealE R McFadden
Apr 1, 1980·Environmental Health Perspectives·S I Wasserman
Apr 1, 1984·Environmental Health Perspectives·S I Wasserman
May 1, 1982·Clinical and Experimental Dermatology·A K Black
Dec 1, 1980·Clinical and Experimental Dermatology·M W Greaves
May 4, 2004·Immunology and Allergy Clinics of North America·Alan A Wanderer, Hal M Hoffman
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·S I Wasserman, D M Center
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·P C AtkinsF Rosenblum
May 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M McHugh, P W Ewan
Oct 1, 1988·The British Journal of Dermatology·M W Greaves
Aug 1, 1981·The Australasian Journal of Dermatology·A R Ahmed, R Moy
Oct 1, 1987·Acta Paediatrica Japonica; Overseas Edition·T NagakuraT Otani
Nov 1, 1981·International Journal of Dermatology·A R Ahmed, R Moy
Jan 1, 1980·International Journal of Dermatology·S I Wasserman
Sep 1, 1983·International Journal of Dermatology·R F Lemanske, M A Kaliner
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela CarlosFernando Q Cunha
Jul 1, 1983·Clinical Allergy·V Songsiridej, W W Busse

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.