Colesevelam HCl improves fasting plasma glucose and lipid levels in patients with prediabetes

Postgraduate Medicine
Yehuda HandelsmanMichael R Jones

Abstract

Although colesevelam hydrochloride (HCl) is indicated to reduce low-density lipoprotein cholesterol (LDL-C) in patients with hyperlipidemia and improve glycemic control in patients with type 2 diabetes, its effects on glucose and lipids in patients with prediabetes have not been previously studied. To evaluate the effects of colesevelam HCl in patients with prediabetes, a post-hoc analysis was conducted on data from a 24-week lipid-lowering study. Using baseline laboratory safety data for fasting plasma glucose (FPG), 88 patients were identified as having prediabetes according to American Diabetes Association criteria. Fasting plasma glucose was reduced by 4.0 mg/dL with colesevelam HCl 3.8 g/day and by 6.1 mg/dL with colesevelam HCl 4.5 g/day compared with placebo. Additionally, LDL-C was reduced by 13.2% and 12.0% with colesevelam HCl 3.8 and 4.5 g/day, respectively, versus placebo. Colesevelam HCl 3.8 g/day also significantly reduced total cholesterol and apolipoprotein (apo)B levels, whereas no significant difference in high-density lipoprotein cholesterol, apoA-I, or triglyceride levels was observed versus placebo. In patients with hyperlipidemia and prediabetes, colesevelam HCl improved glycemic control and the lipid prof...Continue Reading

References

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Citations

Oct 21, 2010·The Mount Sinai Journal of Medicine, New York·Ivana Lukacova-Zib, Geetha Gopalakrishnan
Aug 5, 2011·The American Journal of Cardiology·Gloria Lena VegaScott M Grundy
May 6, 2011·Diabetes Care·Yehuda Handelsman
Aug 5, 2011·Journal of Pharmacy Practice·Luigi Brunetti, R Keith Campbell
Jun 17, 2010·The Annals of Pharmacotherapy·Luigi Brunetti, Evelyn R Hermes-Desantis
Jul 17, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yehuda HandelsmanStacey L Abby

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