Colistin Increases the Cidal Activity of Antibiotic Combinations Against Multidrug-Resistant Klebsiella pneumoniae: An In Vitro Model Comparing Multiple Combination Bactericidal Testing at One Peak Serum Concentration and Time-Kill Method

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Maria Lina MezzatestaStefania Stefani

Abstract

The lack of treatment for multidrug-resistant (MDR) Enterobacteriaceae often leads to the use of double or triple antibiotic combinations to increase the option of clinical success. This study analyzes multiple combination bactericidal testing (MCBT) to screen double and triple antibiotic combinations, at standard peak serum concentration, for bactericidal activity against 21 MDR Klebsiella pneumoniae isolates. This method was compared with time-killing curves. The full bactericidal activity against all strains was obtained only by adding colistin. MCBT has a potential to become a rapid method for testing multiple antibiotic combinations for MDR microorganisms when colistin is used, providing clinicians with in vitro cidal data within 48 hr of strain isolation.

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Jul 26, 2014·International Journal of Antimicrobial Agents·Maria Lina MezzatestaStefania Stefani

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Citations

Jun 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristiane Santos Silva E Silva FigueiredoMarcos Augusto Grigolin Grisotto
Jun 6, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Floriana GonaMaria Lina Mezzatesta
Jan 24, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Hoda Mohamed OwaisMarwa Ahmed Meheissen
Apr 16, 2021·International Journal of Antimicrobial Agents·Luigia ScudellerEvelina Tacconelli

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