Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017)

Frontiers in Microbiology
Virginia CarforaAlessia Franco

Abstract

Colistin-resistance mediated by mobilisable and plasmid-borne mcr genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant Enterobacteriaceae. In this study, we report the first evidence of mcr-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 Salmonella infantis from the Italian antimicrobial resistance (AMR) monitoring (2001-2017) in broilers and broiler meat. Two were also Extended Spectrum Beta-Lactamases (ESBL)-producing isolates. Characterization by whole genome sequencing (WGS), located mcr-1.1 on an incX4 plasmid. Phylogenetic analysis of these isolates with selected Italian S. Infantis previously isolated from animals, meat and human clinical cases with unknown epidemiological relationship, demonstrated that ESBL-producing, mcr-1-positive isolates belonged to the emerging pESI-like-positive-ESBL-producing clone described in Italy in 2015.

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Citations

Mar 11, 2020·The Journal of Antimicrobial Chemotherapy·Carla Adriana Dos SantosMonique Ribeiro Tiba-Casas
Feb 19, 2019·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (EFSA BIOHAZ Panel)Robert Davies
Jul 7, 2020·EFSA Journal·UNKNOWN European Food Safety Authority and European Centre for Disease Prevention and Control (EFSA and ECDC)
Jan 12, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nadia ChaalalAlix Pantel
Mar 2, 2021·Frontiers in Microbiology·Kuan YaoMaria Hoffmann
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Thobeka P MthembuMohamed E El Zowalaty
May 22, 2021·Veterinary Microbiology·Lapo Mughini-GrasMarieke Opsteegh

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Software Mentioned

SPAdes
ResFinder
iTOL
BWA
BLAST
genomeCoverageBed
TrimmomaticPE
FastTree
CSI Phylogeny
BEDTools

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