Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ali FouadAshraf Ghanem

Abstract

A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.

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Citations

Jan 8, 2020·Journal of Separation Science·Lin-Feng HuFeng-Qing Yang
Apr 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Elizabeth TiritanCarla Fernandes

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Methods Mentioned

BETA
High Performance Liquid Chromatography
Scanning electron microscopy
reversed phase chromatography

Software Mentioned

Shimadzu Lab - Solutions

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