Colistin use in critically ill neonates: A case-control study

Pediatrics and Neonatology
Mehmet Sah İpekErdal Ozbek

Abstract

The aim of this study was to assess the safety and efficacy of colistin use in critically ill neonates. This was a case-control study that included newborn infants with proven or suspected nosocomial infections between January 2012 and October 2015, at two centers in Diyarbakir, Turkey. The clinical and laboratory characteristics and outcomes of patients who received colistin therapy were reviewed and compared to patients who were treated with antimicrobial agents other than colistin during the same period. Forty-seven cases who received intravenous colistin (colistin group) and 59 control patients (control group) were included. There were no significant differences between the groups regarding outcomes and nephrotoxicity, including acute renal failure. Colistin therapy was associated with significantly reduced serum magnesium (1.38 ± 0.39 mg/dL vs. 1.96 ± 0.39 mg/dL, p < 0.001) and hypokalemia (46.8% vs. 25.4%, p = 0.026). The patients who received colistin also had longer hospital stays (43 (32-70) days vs. 39 (28-55) days, p = 0.047), a higher rate of previous carbapenem exposure (40.4% vs. 11.9%, p = 0.001), and a higher age at the onset of infection (13 (10-21) days vs. 11 (9-15) days, p = 0.03). This study showed that col...Continue Reading

Citations

Aug 4, 2018·Paediatric Drugs·Ozkan IlhanEsra Arun Ozer
Dec 18, 2019·Antimicrobial Agents and Chemotherapy·David Aguilera-AlonsoFernando Baquero-Artigao
Dec 24, 2018·Expert Opinion on Pharmacotherapy·Reenu ThomasDaniele Dona'
Dec 29, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Florian WagenlehnerJason M Pogue
Apr 25, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Yasemin Coşkun YavuzLutfullah Altintepe

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