Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport.

Pain
Li-Ya Qiao, John R Grider

Abstract

The role of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in colitis-induced hypersensitivity has been suggested. NGF and BDNF facilitate cellular physiology through binding to receptor tyrosine kinase TrkA and TrkB, respectively. The present study by examining the mRNA and/or protein levels of TrkA and TrkB in the distal colon and in colonic primary afferent neurons in the dorsal root ganglia (DRG) during colitis demonstrated that colitis elicited location-specific changes in the mRNA and protein levels of TrkA and TrkB in colonic primary sensory pathways. In colitis both the TrkA and TrkB protein levels were increased in the L1 and S1 DRGs in a time-dependent manner; however, the level of TrkB mRNA but not TrkA mRNA was increased in these DRGs. Further experiments showed that colitis facilitated a retrograde transport of TrkA protein toward and an anterograde transport of TrkA mRNA away from the DRG, which may contribute to the increased TrkA mRNA level in the distal colon during colitis. Colitis also increased the level of NGF mRNA but not BDNF mRNA in the distal colon. Double staining showed that the expression of TrkA but not TrkB was increased in the specifically labeled colonic afferent neurons i...Continue Reading

References

Jan 16, 1995·The Journal of Comparative Neurology·D E Wright, W D Snider
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H S Phillips, M P Armanini
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S W ThompsonS B McMahon
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Dec 12, 2001·Neuron·F D Miller, D R Kaplan
Feb 25, 2003·Annual Review of Neuroscience·Rosalind A Segal
Aug 6, 2003·The Journal of Biological Chemistry·Tami J KingsburyBruce K Krueger
Aug 28, 2003·Brain Research. Molecular Brain Research·Alba GalanJennifer M A Laird
Dec 25, 2003·The Journal of Comparative Neurology·Li-Ya Qiao, Margaret A Vizzard
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H R BerthoudD Grundy
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tracy D Wilson-GerwingValerie M K Verge
Feb 16, 2005·The Journal of Urology·Vivian Y HuMargaret A Vizzard
Feb 22, 2005·Current Opinion in Neurobiology·Charles L Howe, William C Mobley
Aug 5, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K BielefeldtB M Davis
Aug 19, 2005·Nature·Karen Y WuSamie R Jaffrey
Mar 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jichang LiEmeran A Mayer
Nov 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li-Ya Qiao, Melisa A Gulick
Apr 1, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L-Y QiaoJ R Grider
Apr 2, 2008·Experimental Neurology·Roger D P StanzelMichael G Blennerhassett
Feb 26, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D E KingS J Vanner

❮ Previous
Next ❯

Citations

Dec 9, 2014·Frontiers in Biology·Li-Ya Qiao
Oct 31, 2014·Nature Communications·Jeremy Tsung-chieh ChenJing Hu
Jan 16, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F JardíP Vergara
May 25, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C-M XiaL-Y Qiao
Oct 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F JardíP Vergara
Jul 20, 2016·Journal of Neurogastroenterology and Motility·Mohammad H FarzaeiRoja Rahimi
Apr 26, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J E AguirreS K Sarna
Jun 18, 2019·Current Neuropharmacology·Ana CoelhoCélia Duarte Cruz
Mar 2, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ruobing QuGuang-Yin Xu
Mar 16, 2018·Behavioural Pharmacology·Ana E López-PérezRaquel Abalo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.