Colitis-induced neuroplasticity disrupts motility in the inflamed and post-inflamed colon

The Journal of Clinical Investigation
Gary M Mawe

Abstract

Effective colonic motility involves an intricate pattern of excitatory and inhibitory neuromuscular signals that arise from the enteric neural circuitry of the colon. Recent investigations have demonstrated that inflammation leads to a variety of changes in the physiological properties of the neurons in this circuitry, including hyperexcitability of neurons at the afferent end of the peristaltic reflex, synaptic facilitation, and attenuated inhibitory neuromuscular transmission. Furthermore, links have been established between these changes and disrupted motor activity in the colon, and we now know that some of these changes persist long after recovery from inflammation. It is highly likely that inflammation-induced neuroplasticity, which is not detectable by clinical diagnostics, contributes to disrupted motility in active and quiescent inflammatory bowel disease and in functional gastrointestinal disorders.

References

Nov 11, 1991·Gastroenterology·S N ReddyW J Snape
Sep 1, 1987·The Journal of Physiology·S J BrookesD L Wingate
Nov 1, 1987·Gastroenterology·S S RaoC D Holdsworth
Oct 1, 1994·The American Journal of Physiology·L Carney-Anderson, S K Donaldson
Jan 9, 2001·The Anatomical Record·S J Brookes
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian P ManningGary M Mawe
Feb 4, 2003·The Journal of Physiology·David R LindenGary M Mawe
Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·David R LindenGary M Mawe
Apr 6, 2004·Progress in Neurobiology·John B FurnessNadine Clerc
Dec 14, 2004·The Journal of Comparative Neurology·Sumei LiuJackie D Wood
May 3, 2005·Gastroenterology Clinics of North America·Premysl BercikStephen M Collins
Sep 28, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D R LindenG M Mawe
May 11, 1899·The Journal of Physiology·W M Bayliss, E H Starling
Feb 28, 2008·Current Opinion in Gastroenterology·Jackie D Wood
May 22, 2009·Gastroenterology·Robin Spiller, Klara Garsed
Jul 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H I AkbaraliM Kang
Aug 10, 2010·Journal of Neuroscience Methods·Sheila VignaliMichael Schemann
Mar 24, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M HoffmanG M Mawe
Oct 21, 2011·World Journal of Gastrointestinal Pathophysiology·Hirotada AkihoKazuhiko Nakamura
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
Apr 21, 2012·European Journal of Gastroenterology & Hepatology·Francesc CasellasNatalia Borruel
Sep 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·David R Linden
Jun 5, 2013·The Journal of Physiology·Jane A RobertsGary M Mawe
Jun 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Gary M Mawe, Jill M Hoffman
Jan 15, 2014·World Journal of Gastroenterology : WJG·Gabrio BassottiVito Annese
Feb 20, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T Piche
Mar 8, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y NasserS Vanner
May 7, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BashashatiM Simrén
Jul 9, 2014·Nature Reviews. Gastroenterology & Hepatology·Stuart M Brierley, David R Linden
Oct 9, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E CarboneS J H Brookes

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Citations

Mar 22, 2016·Developmental Biology·Robert O Heuckeroth, Karl-Herbert Schäfer
May 13, 2015·Nature Reviews. Gastroenterology & Hepatology·Rose A WillemzeWouter J de Jonge
May 6, 2016·Frontiers in Immunology·Andrea I LoewendorfMike Harrington
May 5, 2016·Gastroenterology·Stephen VannerDavid Grundy
Jun 13, 2016·Trends in Immunology·Kara Gross MargolisMilena Bogunovic
Feb 26, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E CarboneK Nurgali
May 18, 2016·Journal of Neurogastroenterology and Motility·Sutheera Ratanasirintrawoot, Nipan Israsena
Jul 28, 2016·Trends in Neurosciences·Kara Gross Margolis, Michael D Gershon
Apr 13, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E T SpearG M Mawe
Jan 14, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan E LomaxPaul P Bertrand
Jun 22, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jesse J DiCelloDaniel P Poole
Jul 4, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R T FilipponeK Nurgali
Sep 5, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Diana GallegoMarcel Jimenez
May 8, 2019·Acta Physiologica·Michael SchemannPaul Enck
May 16, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jesse J DiCelloDaniel P Poole
Apr 20, 2017·Stem Cell Research & Therapy·Ainsley M RobinsonKulmira Nurgali
Aug 16, 2017·World Journal of Gastroenterology : WJG·Magdy El-SalhyJan Gunnar Hatlebakk
Dec 12, 2018·Neural Regeneration Research·Amanda R White, Gregory M Holmes
May 31, 2018·Physiological Reports·Rika SawadaYasutake Shimizu
Aug 11, 2020·World Journal of Gastroenterology : WJG·Dipesh H Vasant, Alexander C Ford
Mar 3, 2015·The Journal of Clinical Investigation·Diego V Bohórquez, Rodger A Liddle
Aug 28, 2020·Frontiers in Immunology·Luca AntonioliCorrado Blandizzi
Feb 10, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Vijay L KumarHilal Ahmad
May 18, 2020·Current Drug Targets·Rhian StavelyKulmira Nurgali
Mar 27, 2021·Cellular and Molecular Life Sciences : CMLS·Amy Marie HollandWerend Boesmans
May 24, 2021·Gastroenterología y hepatología·Edith Pérez de ArcePilar Nos
Jul 27, 2021·Gastroenterology Clinics of North America·Edith Pérez de ArceEamonn M M Quigley
Dec 31, 2017·Gastroenterology·Lin ChangJohn W Wiley
Sep 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Jackson L K YipElisa L Hill-Yardin

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Methods Mentioned

BETA
motility assay

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