PMID: 7541393Apr 1, 1995Paper

Colitis reduces short-circuit current response to inflammatory mediators in rat colonic mucosa

Inflammation
J F KachurT S Gaginella

Abstract

Inflammatory mediators may contribute to the diarrhea associated with colitis. Although the secretory action of such mediators is reported in normal tissue, there is little information regarding their effects on inflamed tissue. We examined the short-circuit current response (Isc) to these mediators, in mitomycin-C (MC)-induced colitis, a model with histological similarities to colitis in man. Rats were injected once with MC (3.25 mg/kg, intraperitoneally) or vehicle. The colons were removed three and seven days later and mounted, devoid of muscularis, in Ussing chambers for measurement of Isc, potential difference (PD), and resistance (Rt). MC-treated rats had diarrhea after three days, and microscopic studies revealed colonic inflammation. There were no significant differences in Rt, PD, and Isc between control and MC-treated tissues at three and seven days. Maximal increases in Isc to bradykinin, prostaglandin E1, carbachol, substance P, and serotonin were depressed at three and/or seven days after MC. The Isc response to theophylline was not affected. Theophylline activates secretion through an intracellular mechanism; the other agonists act by interaction with epithelial cell membranes. Therefore, the mechanism for the dec...Continue Reading

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Citations

Jul 16, 2008·Inflammatory Bowel Diseases·Olga Martínez-AugustinFermín Sánchez de Medina
Feb 18, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·R Pérez-NavarroF Sánchez de Medina
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Nov 1, 2006·Inflammatory Bowel Diseases·Torsten KucharzikWolfram Domschke
Dec 20, 2013·European Journal of Applied Physiology·Katrin GutekunstFrank-Christoph Mooren
Sep 15, 2004·International Journal of Radiation Biology·A RopengaN M Griffiths
Sep 19, 2006·British Journal of Pharmacology·C L Hirota, D M McKay
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julia EwaschukKaren Madsen
Oct 24, 2006·Annals of the New York Academy of Sciences·Ursula SeidlerBrigitte Riederer
Jul 1, 2008·British Journal of Pharmacology·G SchultheissM Diener
Feb 1, 2005·Life Sciences·Rubén Pérez-NavarroFermín Sánchez de Medina
Oct 28, 2005·The American Journal of Pathology·Stella R ZamunerJohn L Wallace
Dec 1, 1995·Gastroenterology·T S GaginellaA Keshavarzian
Oct 21, 2016·Clinical and Experimental Pharmacology & Physiology·Kim E Barrett, Declan F McCole
Mar 22, 2018·American Journal of Physiology. Cell Physiology·Trey S RottgenVazhaikkurichi M Rajendran
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Edward S KimballPamela J Hornby
Jan 24, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alfred E ChappellDeclan F McCole
May 10, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephanie J KingDeclan F McCole
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E S KimballP J Hornby
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Mar 10, 1999·The American Journal of Physiology·N RadojevicK Croitoru
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paula MiceliStephen Vanner
Aug 11, 2018·Pflügers Archiv : European journal of physiology·Isabel Romero-CalvoFermín Sánchez de Medina
Mar 10, 1999·The American Journal of Physiology·S AsfahaW K MacNaughton
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S AsfahaJ L Wallace
Jul 9, 1998·The American Journal of Physiology·D M McKayJ Lu

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