Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue

Scandinavian Journal of Gastroenterology
J BryndováJirí Pácha

Abstract

Pro-inflammatory processes are counteracted by anti-inflammatory factors such as glucocorticoids. The response of target cells to glucocorticoids depends on several factors including prereceptor modulation of glucocorticoid signals via local glucocorticoid metabolism. This is determined by two isoforms of 11beta-hydroxysteroid dehydrogenase (11betaHSD); 11betaHSD1 operates in vivo as a reductase converting inactive 11-oxo glucocorticoids to active glucocorticoids cortisol or corticosterone, whereas 11betaHSD2 catalyses oxidation of active glucocorticoids to their inactive 11-oxo derivatives. The aim of this study was to investigate the changes in local metabolism of glucocorticoids and in the expression of 11betaHSD1 and 11betaHSD2 mRNA during colonic inflammation. Acute colitis was induced by intracolonic administration of 2,4,6-trinitrobenzenesulphonic acid (TNBS) or by drinking a dextran sodium sulphate (DSS) solution. Metabolism of glucocorticoids was measured in tissue fragments in vitro and 11betaHSD1 and 11betaHSD2 mRNA abundance was quantified using real-time RT-PCR one week after administration of TNBS and 10 days after drinking the DSS solution. In both models of inflammatory bowel disease we observed down-regulation ...Continue Reading

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Citations

Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Sárka ZbánkováJirí Pácha
Apr 26, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Peter ErgangJiří Pácha
Jan 5, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Claudia A Staab, Edmund Maser
Nov 1, 2008·Molecular and Cellular Endocrinology·Karen E ChapmanJonathan R Seckl
Mar 4, 2014·Annals of the New York Academy of Sciences·Rowan S HardyMark S Cooper
Feb 26, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Karen E ChapmanJonathan R Seckl
Jul 20, 2016·Journal of Dermatological Science·Mika Terao, Ichiro Katayama
Dec 21, 2007·Digestive Diseases and Sciences·P ErgangJ Pácha
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Mark S Cooper, Paul M Stewart
Nov 18, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Lijie JiangYinyan Lai
May 1, 2021·International Journal of Molecular Sciences·Peter ErgangJiří Pácha

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