PMID: 9557653Apr 29, 1998Paper

Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system

Journal of Virology
D Craig HooperBernhard Dietzschold

Abstract

To investigate the involvement of various cellular and humoral aspects of immunity in the clearance of rabies virus from the central nervous system, (CNS), we studied the development of clinical signs and virus clearance from the CNS in knockout mice lacking either B and T cells, CD8+ cytotoxic T cells, B cells, alpha/beta interferon (IFN-alpha/beta) receptors, IFN-gamma receptors, or complement components C3 and C4. Following intranasal infection with the attenuated rabies virus CVS-F3, normal adult mice of different genetic backgrounds developed a transient disease characterized by loss of body weight and appetite depression which peaked at 13 days postinfection (p.i.). While these animals had completely recovered by day 21 p.i., mice lacking either B and T cells or B cells alone developed a progressive disease and succumbed to infection. Mice lacking either CD8+ T cells, IFN receptors, or complement components C3 and C4 showed no significant differences in the development of clinical signs by comparison with intact counterparts having the same genetic background. However, while infectious virus and viral RNA could be detected in normal control mice only until day 8 p.i., in all of the gene knockout mice studied except those ...Continue Reading

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Citations

Sep 29, 2005·Journal of Virology·Christophe PréhaudMonique Lafon
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy W PharesD Craig Hooper
May 2, 2008·Current Opinion in Infectious Diseases·Mary J Warrell
Feb 26, 2013·Viruses·Timothy W PharesCornelia C Bergmann
Oct 3, 2013·The Journal of General Virology·Vythegi SrithayakumarChristopher J Kyle
May 31, 2003·Nature Reviews. Immunology·Diane E Griffin
Apr 5, 2005·Journal of Neurovirology·D Craig Hooper
Oct 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marzena J FabisD Craig Hooper
Jun 18, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Zenon Steplewski, Thomas Kieber-Emmons
Jan 9, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sawang KesdangsakonwutTakashi Umemura
Feb 5, 2015·Clinical and Experimental Vaccine Research·Manjunatha Muniswamappa VenkataswamyNandita Hazra
Jan 3, 2015·Journal of the American Veterinary Medical Association·Michael C MooreDerek A Mosier
May 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LuoXiaofeng Guo
Oct 22, 2002·The Journal of General Virology·N JohnsonA R Fooks
Nov 5, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A VosA C Jackson
Sep 12, 2006·Journal of Clinical Immunology·Susan M MooreDeborah J Briggs
Nov 13, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Louise C AllenGary F McCracken
Jun 21, 2011·Future Virology·D Craig HooperDarryll A Barkhouse
Jun 1, 2010·Journal of Medical Virology·M HunterA R Fooks
Apr 29, 2011·Journal of Virology·Damien ChopyMonique Lafon
Aug 3, 2012·The American Journal of Tropical Medicine and Hygiene·Amy T GilbertCharles Rupprecht
Aug 7, 2012·Clinical and Experimental Immunology·D J HicksN Johnson
Aug 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir HorowitzEleanor M Riley
Nov 19, 2014·The Pediatric Infectious Disease Journal·Yolanda CaicedoRodney E Willoughby
Jun 2, 2009·Journal of Feline Medicine and Surgery·Tadeusz FrymusMarian C Horzinek

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