Collaborative care for patients with bipolar disorder: randomised controlled trial

The British Journal of Psychiatry : the Journal of Mental Science
Trijntje Y G van der VoortRalph W Kupka

Abstract

A substantial number of people with bipolar disorder show a suboptimal response to treatment. To study the effectiveness of a collaborative care programme on symptoms and medication adherence in patients with bipolar disorder, compared with care as usual. A two-armed, cluster randomised clinical trial was carried out in 16 out-patient mental health clinics in The Netherlands, in which 138 patients were randomised. Patient outcomes included duration and severity of symptoms and medication adherence, and were measured at baseline, 6 months and 12 months. Collaborative care comprised contracting, psychoeducation, problem-solving treatment, systematic relapse prevention and monitoring of outcomes. Mental health nurses functioned as care managers in this programme. The trial was registered with The Netherlands Trial Registry (NTR2600). Collaborative care had a significant and clinically relevant effect on number of months with depressive symptoms, both at 6 months (z = -2.6, P = 0.01, d = 0.5) and at 12 months (z = -3.1, P = 0.002, d = 0.7), as well as on severity of depressive symptoms at 12 months (z = -2.9, P = 0.004, d = 0.4). There was no effect on symptoms of mania or on treatment adherence. When compared with treatment as usu...Continue Reading

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Citations

Jul 15, 2015·Annals of General Psychiatry·Stella MiziouKonstantinos N Fountoulakis
Apr 5, 2015·Journal of Affective Disorders·Trijntje Y G van der VoortRalph W Kupka
Apr 16, 2016·International Journal of Psychiatry in Medicine·Lindsay M Avery, Shannon J Drayton
Feb 6, 2019·Psychiatric Services : a Journal of the American Psychiatric Association·Joseph M CerimeleJohn C Fortney
Mar 29, 2018·Current Psychiatry Reports·Ludovic SamalinPierre-Michel Llorca
Sep 11, 2020·Primary Health Care Research & Development·Emily S MillerEydie L Moses-Kolko
Dec 2, 2020·Journal of Psychiatric and Mental Health Nursing·Kirsten Kjaer JohansenJens Peter Hansen
Mar 21, 2021·Psychology and Psychotherapy·Jannis T KraissErnst T Bohlmeijer

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