Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Lanqing WangJames L Pirkle

Abstract

Background: Biomarkers of tobacco exposure have a central role in studies of tobacco use and nicotine intake. The most significant exposure markers are nicotine itself and its metabolites in urine. Therefore, it is important to evaluate the performance of laboratories conducting these biomarker measurements.Methods: This report presents the results from a method performance study involving 11 laboratories from 6 countries that are currently active in this area. Each laboratory assayed blind replicates of seven human urine pools at various concentrations on three separate days. The samples included five pools blended from smoker and nonsmoker urine sources, and two additional blank urine samples fortified with pure nicotine, cotinine, and hydroxycotinine standards. All laboratories used their own methods, and all were based on some form of liquid chromatography/tandem mass spectrometry.Results: Overall, good agreement was found among the laboratories in this study. Intralaboratory precision was good, and in the fortified pools, the mean bias observed was < + 3.5% for nicotine, approximately 1.2% for hydroxycotinine, and less than 1% for cotinine (1 outlier excluded in each case). Both indirect and direct methods for analyzing th...Continue Reading

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Citations

Nov 6, 2018·Journal of Analytical Toxicology·Honest AchilihuJohn T Bernert
Mar 11, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob
Dec 14, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Peyton JacobNeal L Benowitz
May 23, 2018·International Journal of Environmental Research and Public Health·Sungroul Kim, Sol Yu
Apr 17, 2021·Journal of Analytical Toxicology·Roberto Bravo CardenasLiza Valentin-Blasini
May 6, 2021·International Journal of Environmental Research and Public Health·Guillaume RudasingwaSungroul Kim
May 2, 2021·The Journal of Biological Chemistry·Sharon E Murphy

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