PMID: 15220736Jun 29, 2004Paper

Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA

Cornea
Gregor WollensakTheo Seiler

Abstract

Collagen crosslinking of the cornea has been developed recently as a quasiconservative treatment of keratoconus. Biomechanical in vitro measurements have demonstrated a significant increase in biomechanical stiffness of the crosslinked cornea. The aim of the present study was to evaluate the effect of this new procedure on the collagen fiber diameter of the rabbit cornea. The corneas of the right eyes of 10 New Zealand White albino rabbits were crosslinked by application of the photosensitizer riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes. The left fellow control eyes were either left untreated (rabbits 1-4), deepithelialized (rabbits 5-7), or deepithelialized and treated with riboflavin/dextran solution (rabbits 8-10) to exclude an influence of epithelial debridement or hydration changes on the fiber diameter. On ultrathin sections of samples from the anterior and posterior cornea, the collagen fiber diameter was measured semiautomatically with the help of morphometric computer software. In the anterior stroma, the collagen fiber diameter in the treated corneas was significantly increased by 12.2% (3.96 nm), and in the posterior stroma by 4.6% (1.63 nm), compared with the control fellow eyes. In the cr...Continue Reading

References

Sep 20, 1988·Journal of Molecular Biology·S TanakaE F Eikenberry
Jul 1, 1988·Experimental Eye Research·U P Andley, B A Clark
Jun 1, 1969·Journal of the Optical Society of America·R W Hart, R A Farrell
Mar 6, 1998·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E SpörlT Seiler
Jun 17, 1998·Experimental Eye Research·E SpoerlT Seiler
Dec 5, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J FaulbornS Bowald
Jan 12, 1999·Mechanisms of Ageing and Development·A J BaileyL Knott
May 2, 2000·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E SpörlP Knuschke
Apr 30, 2003·American Journal of Ophthalmology·Gregor WollensakTheo Seiler

❮ Previous
Next ❯

Citations

Aug 2, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M Kohlhaas
Dec 23, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria GkikaVassilios Kozobolis
Jun 26, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Georgios A KontadakisIoannis G Pallikaris
Apr 29, 2005·Micron : the International Research and Review Journal for Microscopy·Michael J Doughty, Jan P G Bergmanson
Apr 30, 2003·American Journal of Ophthalmology·Gregor WollensakTheo Seiler
Oct 3, 2003·Journal of Cataract and Refractive Surgery·Gregor WollensakTheo Seiler
May 22, 2010·Cornea·Kátia Mantovani BottósHelena B Nader
May 29, 2010·Cornea·Gregor Wollensak, Hermann Herbst
Mar 16, 2012·Cornea·Aldo CaporossiAngelo Balestrazzi
May 15, 2012·Cornea·Elisabeth M MessmerClaudia Auw-Haedrich
Jul 9, 2010·International Ophthalmology Clinics·Konstantinos E Samaras, Damian B Lake
Jan 31, 2012·Journal of Ophthalmology·Marine HovakimyanOliver Stachs
Jun 28, 2013·BMC Veterinary Research·Anna Hellander-EdmanBjörn Ekesten
Aug 12, 2009·Clinical Ophthalmology·Oren Tomkins, Hanna J Garzozi
Jan 1, 2009·Oman Journal of Ophthalmology·Maria Clara ArbelaezSanak Roy Choudhury
Sep 6, 2013·Journal of Materials Science. Materials in Medicine·Harvey RichLaurent Bozec
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Praveen R AranyAnita B Roberts
Aug 29, 2014·Journal of Ophthalmology·Cosimo MazzottaMiguel Rechichi
Jun 1, 2014·Journal of Cataract and Refractive Surgery·Gilad LitvinGuy Kleinmann
Sep 7, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Tobias BrockmannJens Dawczynski
Jul 23, 2013·Ophthalmic Research·Vimalin JeyalathaHajib N Madhavan
Aug 11, 2006·Current Opinion in Ophthalmology·Gregor Wollensak
Sep 5, 2013·Expert Opinion on Drug Metabolism & Toxicology·Clara C Chan, Victoria Squissato
Jun 8, 2010·Expert Opinion on Drug Safety·Sai Kolli, Ioannis M Aslanides

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cataract and Refractive Surgery
Frederik Raiskup-WolfLutz Pillunat
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Eberhard SpoerlTheo Seiler
© 2022 Meta ULC. All rights reserved