Collagen-induced arthritis in mice. VI. Synovial cells from collagen arthritic mice activate autologous lymphocytes in vitro

Cellular Immunology
P H WooleyJ M Chapdelaine

Abstract

Synovial cells were extracted from normal and collagen-arthritic mice and investigated for lymphocyte-activating properties. In mixed cell culture, irradiated fibroblast-like synovial cells from DBA/1 LacJ arthritic mice stimulated a strong proliferative response in spleen cells from syngeneic normal mice, but not in cells from allogeneic DBA/2. B10.RIII, or BALB/c mice. This novel stimulus occurred in the absence of detectable Class II MHC antigen expression on the fibroblast-like synovial cell surface or increased autologous mixed lymphocyte reactions between DBA/1 LacJ spleen and lymph node cells. Irradiated synovial cells were also unable to present type II collagen to a collagen-specific T cell line and to stimulate proliferation. Addition of interferon-gamma or interleukin-1 failed to induce detectable surface Ia on the synovial fibroblasts or induce the capacity for antigen presentation in these cells.

References

Jan 1, 1978·Immunological Reviews·J E Niederhuber
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Dec 1, 1986·Immunological Reviews·G F BottazzoR Pujol-Borrell
Apr 1, 1985·Cellular Immunology·M L TikuJ L Skosey
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Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L KlareskogH Wigzell

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Citations

May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J LuM Adachi
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina L RoarkRebecca L O'Brien

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