Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig

The Journal of Clinical Investigation
D B KnoerzerL J Mengle-Gaw

Abstract

Antigen-specific T cell activation requires two independent signalling events, one mediated through T cell receptor engagement by the antigen-presenting cell-expressed peptide/class II major histocompatibility complex, and the second through the cognate interactions of costimulatory molecules expressed on the T cell and antigen-presenting cell. There is evidence from in vitro and in vivo experimental systems suggesting that the CD28/B7 costimulatory pathway is crucial for induction of maximal T cell proliferation and T helper-B cell collaboration for IgG production. This pathway can be blocked by CTLA-4-Ig, a soluble form of CTLA-4 which binds with high avidity to the CD28 ligands, B7-1 and B7-2. Here, we show that CTLA-4-Ig treatment prevents clinical and histological manifestations of disease in a collagen-induced arthritis model of rheumatoid arthritis in the diabetes resistant BB/Wor rat, when therapy is initiated before immunization with bovine type II collagen (BIIC). Anti-BIIC antibody titers are reduced in CTLA-4-Ig-treated rats compared to diseased control animals. Histologically, joints from CTLA-4-Ig-treated animals show no histological abnormalities, in contrast to control antibody-treated animals, which show comple...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D GimmiL M Nadler
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S LinsleyJ A Ledbetter
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P H SchreierD Baltimore
Aug 1, 1982·Arthritis and Rheumatism·D E Trentham
Aug 26, 1994·Science·B K FinckD Wofsy
Sep 1, 1994·Immunity·J M GreenC B Thompson
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter

❮ Previous
Next ❯

Citations

Nov 9, 2000·European Journal of Immunology·T YoshiokaK Okumura
Mar 1, 1997·Arthritis and Rheumatism·L W MorelandW J Koopman
Apr 25, 2000·Biochemical and Biophysical Research Communications·Y SatakeK Okumura
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
Jun 2, 2006·Springer Seminars in Immunopathology·Mary K Crow
Mar 5, 2009·Journal of Clinical Immunology·Julie A CarmanSteven G Nadler
Jan 19, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph R Podojil, Stephen D Miller
Aug 21, 2013·Trends in Immunology·Sabrina CeerazRandolph J Noelle
Nov 30, 2010·Nature Chemical Biology·Julie A Di PaoloKevin S Currie
Mar 14, 2012·Nature Reviews. Rheumatology·Josef S SmolenKurt Redlich
Jun 2, 1998·Kidney International·C J KellyD P Gold
Oct 31, 1996·The New England Journal of Medicine·H Reiser, M J Stadecker
Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M GiorelliM Trojano
Sep 11, 2007·Thyroid : Official Journal of the American Thyroid Association·Eric M Jacobson, Yaron Tomer
Feb 12, 1998·Tissue Antigens·C SeidlK Badenhoop
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·I C ChikanzaD R Blake
Jul 15, 2005·Annals of Periodontology·George HajishengallisRobert J Genco
Aug 6, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Hanns-Martin Lorenz
Mar 30, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Stamatis-Nick C Liossis, Petros P Sfikakis
Dec 1, 2012·International Journal of Biological Sciences·Yan-Ling WuHiroshi Sugiyama
Sep 22, 2005·Current Rheumatology Reports·Sarah L MackiePaul Emery
Jun 9, 2011·Expert Opinion on Biological Therapy·Charalampos Papagoras, Alexandros A Drosos
Aug 30, 2005·Autoimmunity·Dan HolmbergVinicius Motta
Jul 7, 2012·Reumatología clinica·Emilio Martín MolaUNKNOWN Spanish expert panel of rheumatologists
Mar 25, 2009·Journal of Autoimmunity·Yaron Tomer, Amanda Huber
Oct 20, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patricia M DavisSuzanne J Suchard
Aug 4, 2015·Journal of Autoimmunity·Hanna J LeeYaron Tomer
Apr 1, 2015·European Journal of Pharmacology·Kay McNameeMichael Seed
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E M Bolton, J A Bradley
Feb 21, 2009·Basic & Clinical Pharmacology & Toxicology·Riku Korhonen, Eeva Moilanen
May 12, 2009·Immunological Reviews·Peter S Linsley, Steven G Nadler
Sep 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amy DhirapongM Eric Gershwin
Aug 19, 2009·Basic & Clinical Pharmacology & Toxicology·Riku Korhonen, Eeva Moilanen
Jul 4, 2015·Arthritis & Rheumatology·Paola Mina-Osorio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.