PMID: 9550266Apr 29, 1998Paper

Collagen IX: evidence for a structural association between NC4 domains in cartilage and a novel cleavage site in the alpha 1(IX) chain

Matrix Biology : Journal of the International Society for Matrix Biology
S P DouglasK E Kadler

Abstract

Collagen IX, a structural component of the extracellular matrix of connective tissues, is synthesized as long and short forms which contain or lack, respectively, a 27 kDa non-collagenous (NC) 4 domain at the N-terminus of the alpha 1(IX) chain of the molecule. The long form occurs in cartilage and developing cornea, but not in vitreous, suggesting a specialized function for the NC4 domain, perhaps by interacting with other macromolecules. To test this hypothesis, embryonic chick cartilage was treated with DTSSP, dissociated with bacterial collagenase, and the NC4-containing DTSSP-cross-linked protein complexes examined and purified. Analysis of cartilage extracts using an anti-NC4 antibody, and of purified NC4-containing complexes, identified a predominant NC4 dimer. A naturally-occurring N-terminal fragment of the alpha 1(IX) chain, whose size is equivalent to the NC4-COL3-NC3 domains of the chain, was identified. Association of collagen IX molecules via NC4 domains and the existence of a cleavage site close to the NC3 domain of the molecule are likely to be of primary importance in the growth and remodeling processes of cartilage, in health and disease.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y MuragakiB R Olsen
Jan 1, 1989·The Journal of Cell Biology·M MendlerP Bruckner
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K K SvobodaB R Olsen
Mar 1, 1988·The Journal of Cell Biology·L VaughanR Mayne
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G LozanoB R Olsen
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y Ninomiya, B R Olsen
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·R FässlerR Jaenisch
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K NakataT Kimura
Aug 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H B HaimesB R Olsen
Apr 1, 1997·The International Journal of Biochemistry & Cell Biology·B R Olsen

❮ Previous
Next ❯

Citations

Apr 5, 2000·Progress in Retinal and Eye Research·P N Bishop
Dec 31, 2003·The Journal of Biological Chemistry·Julia Thom OxfordSorcha Cusack
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fackson MwaleA Robin Poole
Nov 11, 2008·Connective Tissue Research·Anne Vaughan-ThomasVictor C Duance
Jul 25, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F MwaleA R Poole
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John M FitchThomas F Linsenmayer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
A Arciniegas, L E Amaya
Developmental Dynamics : an Official Publication of the American Association of Anatomists
F MwaleA R Poole
Matrix Biology : Journal of the International Society for Matrix Biology
M Moradi-AméliM van der Rest
© 2022 Meta ULC. All rights reserved