PMID: 9544892Apr 17, 1998Paper

Collagen metabolism and growth in prepubertal children with asthma treated with inhaled steroids

The Journal of Pediatrics
S CrowleyC G Brook

Abstract

To investigate growth and markers of collagen and bone metabolism in prepubertal children with asthma. We measured growth velocity over 12 months and markers of collagen types I and III synthesis (PINP, PICP, PIIINP), collagen type I degradation (ICTP), and bone metabolism (bone-specific alkaline phosphatase and osteocalcin) on one occasion in 56 prepubertal children with stable asthma, 39 of whom were treated with inhaled budesonide or beclomethasone. Collagen data were compared with normal control values. Children treated with inhaled steroids had reduced collagen synthesis (PINP, PIIINP) compared with control subjects (p = 0.038, p = 0.045), although PICP was increased (p = 0.05). Carboxyterminal telopeptide of type I collagen was reduced in patients treated with inhaled steroids (p < 0.0005) compared with nonsteroid-treated patients. Serum osteocalcin but not bone-specific alkaline phosphatase was significantly reduced in children treated with inhaled steroids (p < 0.02). Significant correlation was observed between PIIINP and ICTP and growth velocity. Collagen turnover is reduced in children with asthma receiving long-term inhaled steroid treatment. Markers of collagen synthesis provide a more accurate reflection of growth...Continue Reading

Citations

Feb 13, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·N TangsinmankongR A Good
Mar 17, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·E O Meltzer
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·S Pedersen
Jan 22, 2011·Pulmonary Pharmacology & Therapeutics·Iwona StelmachPawel Majak
Feb 5, 1999·The Journal of Pediatrics·P L Brand, R J Roorda
May 28, 2015·Pulmonary Pharmacology & Therapeutics·Fabio L M RicciardoloPaola Rogliani
Feb 12, 2002·Pediatric Pulmonology·David B Allen
Jan 20, 2004·Pediatric Pulmonology·Amanda L GriffithsNicholas Freezer
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A D Baxter-Jones, P J Helms
Dec 11, 1999·Current Opinion in Pediatrics·M E Krawiec, S E Wenzel
Jul 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·J M Sondheimer
May 5, 2000·The Cochrane Database of Systematic Reviews·P J Sharek, D A Bergman
Nov 4, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·G JonesA Carmichael
Jan 12, 2000·The Annals of Pharmacotherapy·K V Blake
Apr 21, 2006·The Cochrane Database of Systematic Reviews·J P GuevaraJ Zorc

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.