PMID: 3757543Aug 1, 1986Paper

Collagen metabolism following corneal laceration in rabbits

Current Eye Research
R J CionniW W Kao

Abstract

We investigated the synthesis and degradation of collagen in lacerated rabbit corneas. The rate of collagen synthesis was measured by the incorporation and hydroxylation of [14C]proline up to 5 weeks after a penetrating laceration. Our results indicate that protein and collagen synthesis is initially reduced during the 24 h period after laceration and then increases in two phases. A moderate increase in protein and collagen synthesis occurs up to day 5 after laceration. Synthesis then decreases to a low level through the 10th day after injury. A second wave of increase in protein and collagen synthesis takes place reaching a new peak of approximately twice the activity as found in control corneas after 5 weeks of healing. Afterwards, the rate of protein and collagen synthesis declines and reaches the basal level after 7 weeks of healing. In a separate set of experiments, rabbit corneas were lacerated and allowed to heal for one or three weeks at which point 100 microCi of [14C]proline was injected into each anterior chamber. The corneas were excised 1 to 17 days later and subjected to collagen analysis. Our data indicates that the degradation of collagen synthesized by the cornea 1 week after laceration followed biphasic kineti...Continue Reading

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Citations

Jan 1, 1992·Acta Ophthalmologica. Supplement·M E FiniM Matsubara
Jan 29, 2003·Journal of Cataract and Refractive Surgery·Takeshi MiyamotoYoshitaka Ohnishi
Apr 1, 2004·Molecular & Cellular Proteomics : MCP·Henrik KarringTorben Møller-Pedersen
Nov 16, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·K Keven WilliamsJoseph W Hiddemen
Sep 26, 2015·The British Journal of Ophthalmology·Leopoldo SpadeaPaolo Trabucco
Mar 1, 1991·Experimental Eye Research·J SakaiW W Kao

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