PMID: 9437226Jan 23, 1998Paper

Collagen metabolites in the prediction of response to GH therapy in short children

European Journal of Endocrinology
P TapanainenJ Risteli

Abstract

To evaluate the role of collagen metabolites in the prediction of the response to GH treatment we measured the serum concentrations of the C-terminal propeptide of type I procollagen (PICP) and the N-terminal propeptide of type III procollagen (PIIINP) with specific RIAs in 35 short children (16 boys) before and after 5 days, 5 weeks and 3 months of GH therapy. The mean age of the children was 10.3 years (range 1.9-16.4 years) and the bone age ranged from 1.2 to 12.5 years (mean 7.6 years). The initial mean relative height (RH) was -3.6 SDS (range -6.6 to -2.4 S.D.). Nineteen children were found to have GH deficiency (GHD; peak GH responses in two pharmacological tests < 10 micrograms/l), while the remaining 16 were considered to have undefined short stature (USS). The children were treated with recombinant human GH (0.1 U/kg given subcutaneously at bedtime 6-7 times/week). The increases in RHI over the first 6 and 12 months of therapy were used as response measures. There was already a significant increase (P < 0.001) in both the serum PICP and PIIINP levels at 5 days, and the concentrations continued to rise up to 3 months, PICP levels rising less than the PIIINP levels. In the whole group the RHI over 6 months correlated mos...Continue Reading

Citations

May 18, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·H VierimaaJ Risteli
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·A SartorioG I Baroncelli
Apr 7, 2012·Clinical Biochemistry·Marja-Kaisa KoivulaJuha Risteli
Feb 13, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·P RömerC Reicheneder
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joan C MariniC Michael Reing
Dec 8, 2015·PloS One·Shu SunAnders F Nedergaard
Jun 21, 2007·Journal of Autism and Developmental Disorders·Colleen Taylor Lukens, Thomas R Linscheid

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