Collagen minipellet as a controlled release delivery system for tetanus and diphtheria toxoid

Vaccine
M HigakiY Mizushima

Abstract

The use of biodegradable polymer matrices as a single-dose vaccine delivery system was investigated using tetanus toxoid (TT) and diphtheria toxoid (DT). BALB/c mice were immunized with TT or DT in different formulations including individual, in minipellet and aluminum hydroxide (alum), and the antibody responses were monitored for 48 weeks. Antigens entrapped in minipellet elicited higher antibody responses compared to those obtained with individual antigens and antigens adsorbed to alum and the antibody levels remained elevated over 48 weeks. In addition, minipellet formulations induced the same subclasses of antibodies induced by alum formulations. These results raise the possibility to obtain optimal and long-lasting immune responses by a single administration of minipellet formulations.

References

Mar 1, 1991·Molecular Immunology·A C Allison, N E Byars
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·S P SchwendemanR Langer
Jun 1, 1996·Journal of Pharmaceutical Sciences·A SanchezR Langer
Jun 6, 2000·Advanced Drug Delivery Reviews·A SanoK Fujioka

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Citations

May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isabella SchöllErika Jensen-Jarolim
Oct 5, 2002·Advanced Drug Delivery Reviews·Shari Lofthouse
Dec 19, 2003·Expert Opinion on Biological Therapy·Neelesh K Varde, Daniel W Pack
Aug 9, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kevin J McHughAna Jaklenec
Jul 8, 2005·Biomaterials·Silvia H De Paoli LacerdaNitsa Rosenzweig
Dec 2, 2011·The Journal of Toxicological Sciences·Shingo OgawaIchiro Fujimoto
Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Augustus M KilgoreRoss M Kedl
Oct 20, 2020·Frontiers in Immunology·Gabriel Kristian PedersenDennis Christensen
Nov 25, 2020·Emerging Topics in Life Sciences·Sharan Bobbala, Sarah Hook
Jul 1, 2020·Advanced Drug Delivery Reviews·Darrell J IrvineMurillo Silva
Oct 19, 2017·Journal of Pharmaceutical Sciences·Nattawut LeelakanokAliasger Salem

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