Collagen network primarily controls Poisson's ratio of bovine articular cartilage in compression

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Panu KivirantaJ Jurvelin

Abstract

The equilibrium Young's modulus of articular cartilage is known to be primarily determined by proteoglycans (PGs). However, the relation between the Poisson's ratio and the composition and structure of articular cartilage is more unclear. In this study, we determined Young's modulus and Poisson's ratio of bovine articular cartilage in unconfined compression. Subsequently, the same samples, taken from bovine knee (femoral, patellar and tibial cartilage) and shoulder (humeral cartilage) joints, were processed for quantitative microscopic analysis of PGs, collagen content, and collagen architecture. The Young's modulus, Poisson's ratio, PG content (estimated with optical density measurements), collagen content, and birefringence showed significant topographical variation (p < 0.05) among the test sites. Experimentally the Young's modulus was strongly determined by the tissue PG content (r = 0.86, p < 0.05). Poisson's ratio revealed a significant negative linear correlation (r = -0.59, p < 0.05) with the collagen content, as assessed by the Fourier transform infrared imaging. Finite element analyses, conducted using a fibril reinforced biphasic model, indicated that the mechanical properties of the collagen network strongly affecte...Continue Reading

References

May 28, 1976·Biochimica Et Biophysica Acta·G E KempsonP H Horsfield
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T D Brown, D T Shaw
May 1, 1984·Journal of Biomechanical Engineering·C G ArmstrongV C Mow
Feb 1, 1980·Journal of Biomechanical Engineering·V C MowC G Armstrong
Sep 4, 1999·The Journal of Arthroplasty·R SingermanJ W Kennedy
May 16, 2000·Journal of Biomechanics·J S JurvelinH J Helminen
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W GründerA Werner
Jun 22, 2000·Journal of Magnetic Resonance Imaging : JMRI·Y Xia
Jan 3, 2001·Biopolymers·N P CamachoR Mendelsohn
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M T NieminenJ S Jurvelin
Dec 10, 2003·Cells, Tissues, Organs·Jarno RieppoHeikki J Helminen

❮ Previous
Next ❯

Citations

Jul 10, 2007·Biomechanics and Modeling in Mechanobiology·Salvatore Federico, Walter Herzog
May 9, 2012·Annals of Biomedical Engineering·Spencer P LakeVictor H Barocas
Mar 25, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Li-Lan GaoPeng-Peng Xiao
Jul 28, 2007·Journal of Biomechanical Engineering·Sean S KohlesLawrence J Bonassar
Dec 3, 2008·Journal of Biomechanical Engineering·A J F StopsP E McHugh
Jun 10, 2010·BMC Developmental Biology·Mark C van TurnhoutJohan L van Leeuwen
Apr 27, 2007·PloS One·Philipp LeuchtJill A Helms
Apr 6, 2007·Biomedizinische Technik. Biomedical Engineering·Gunter SpahnGunther O Hofmann
Nov 10, 2009·Journal of Biomedical Optics·Mark C van TurnhoutJohan L van Leeuwen
Oct 17, 2008·Journal of Biomechanics·Salvatore Federico, Walter Herzog
Jul 14, 2007·Journal of Biomechanics·Timothy FicklinStephen M Klisch
Jul 15, 2015·Journal of Biomechanics·J T A MäkeläR K Korhonen
Mar 9, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Valérie Malfroy CamineDominique P Pioletti
Jan 10, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Heonjune RyouDwayne Arola
May 10, 2007·The FEBS Journal·Joseph CandielloHai Lin
Jan 15, 2009·Clinical Orthopaedics and Related Research·Roza MahmoodianSorin Siegler
May 12, 2009·Ultrasound in Medicine & Biology·Pauno LötjönenHeikki J Nieminen
Mar 24, 2007·Journal of Biomedical Materials Research. Part a·Rony SnydersJolanta E Klemberg-Sapieha
Aug 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin D Elder, Kyriacos A Athanasiou
Mar 22, 2014·Soft Matter·George W GreeneRoger Horn
Sep 20, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Miitu K M HonkanenJuha Töyräs
Jun 12, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abhisek BhattaraiJuha Töyräs
Jun 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nina Elina HänninenMikko Johannes Nissi
Jun 5, 2015·Journal of Biomechanical Engineering·Michael E StenderVirginia L Ferguson
Jan 1, 2016·Nature Biomedical Engineering·Hadi T NiaRakesh K Jain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.