Collagen shield delivery of trifluorothymidine

Journal of Cataract and Refractive Surgery
J R GusslerT J Smith

Abstract

Corneal and aqueous levels of topically applied trifluorothymidine (F3T) were compared with and without the collagen shield in normal and damaged rabbit eyes. Shields were presoaked in 1% F3T for 15 minutes prior to application. Rabbits received either a presoaked shield, 1% F3T drops every two hours, or both. Corneal and aqueous levels of F3T were measured at 30 minutes, two, four, and eight hours. If 5 mm epithelial defects were created, the collagen shield and topical F3T drops produced significantly higher levels of F3T than drops alone at all periods tested (P less than .05). A presoaked shield alone produced greater levels of F3T than drops alone at 30 minutes and two hours (P less than .05). Collagen shields did not enhance F3T levels in eyes with intact epithelium. Implications for treatment of herpetic keratouveitis are discussed.

References

Nov 1, 1989·Journal of Cataract and Refractive Surgery·M R SawuschS A Updegraff
Sep 1, 1989·Archives of Ophthalmology·D G HwangL A MacGowan-Smith
Nov 1, 1988·Mayo Clinic Proceedings·T J Liesegang
Sep 1, 1988·Journal of Cataract and Refractive Surgery·S R UntermanH E Kaufman
Sep 1, 1988·Journal of Cataract and Refractive Surgery·T P O'BrienJ D Gottsch
Nov 1, 1988·Archives of Ophthalmology·R B PhinneyB J Mondino
Dec 15, 1988·Annals of Internal Medicine·D A Lindley, C J Schleupner
Feb 1, 1988·The British Journal of Ophthalmology·L D OrmerodR E Smith
Jan 1, 1987·Journal of Pharmaceutical Sciences·P R Byron, R N Dalby
Feb 1, 1987·American Journal of Optometry and Physiological Optics·H B Collin, N Carroll
Jun 1, 1972·American Journal of Ophthalmology·P C WellingsH E Kaufman
Aug 1, 1980·Archives of Ophthalmology·A H WanderH E Kaufman
Mar 1, 1984·The British Journal of Ophthalmology·S O HungP J Rees

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Citations

Jun 9, 2001·International Journal of Pharmaceutics·C H LeeY Lee
Jan 1, 1993·Journal of Cataract and Refractive Surgery·G RenardC Trinquand
Mar 1, 1993·Journal of Cataract and Refractive Surgery·C C ChenE Duzman
Jan 1, 1994·Journal of Ocular Pharmacology·H E KaufmanB M Gebhardt

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