Collagen synthesis and degradation in polyneuropathy and myopathies

Muscle & Nerve
Anne M AhtikoskiAarne Oikarinen

Abstract

To determine the mechanisms underlying the changes in collagen metabolism responsible for muscle fibrosis in patients with neuromuscular diseases, the synthesis and degradation of collagens was studied in muscles of patients with polyneuropathy and noninflammatory myopathies. The mRNA levels for type I, III, and IV collagens and immunohistochemical staining intensities for collagen propeptides and telopeptides were increased in polyneuropathy, suggesting enhanced synthesis of collagens. In myopathy, the mRNA levels were at the control level. Matrix metalloproteinase (MMP)-2 mRNA level was increased in polyneuropathy, although the quantity of proMMP-2 was not changed. An increase in type IV collagen concentration and proMMP-9 expression was observed in polyneuropathy but not in myopathies. Our results suggest that intramuscular accumulation of type IV collagen occurs in polyneuropathy, possibly leading to thickening of the capillary and muscle fiber basement membranes. This may complicate the transportation of nutrients and cellular excreta between blood and muscle cells.

References

Jan 1, 1980·European Journal of Biochemistry·J RisteliR Timpl
Dec 1, 1982·Archives of Neurology·R MyllyläK I Kivirikko
Sep 1, 1981·Collagen and Related Research·J RisteliR Timpl
Dec 1, 1982·Archives of Neurology·L PeltonenV V Myllylä
Mar 1, 1981·Archives of Neurology·M FoidartW K Engel
Sep 1, 1994·Analytical Biochemistry·P Chomczynski, K Mackey
May 1, 1994·Analytical Biochemistry·D E Kleiner, W G Stetler-Stevenson
Aug 1, 1998·The Journal of Biological Chemistry·C TrocméF Morel
Feb 7, 2001·Brain : a Journal of Neurology·B C KieseierH P Hartung
Apr 10, 2002·Acta Neurologica Scandinavica·B G H SchoserH-J Stuerenburg

❮ Previous
Next ❯

Citations

Jul 16, 2011·Lasers in Medical Science·Thais Oricchio Fedri de SouzaManoela Domingues Martins
Oct 27, 2010·Lasers in Surgery and Medicine·Davilene Gigo-BenatoNivaldo Antonio Parizotto
Dec 21, 2010·Biochemical and Biophysical Research Communications·Thomas P VacekSuresh C Tyagi
Jun 13, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Zuleyha Erisgin, Murat Usta
Nov 18, 2016·Journal of Neuromuscular Diseases·A ArvanitidisA Nedergaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.