Mar 15, 1981

Collagen treated with (+)-catechin becomes resistant to the action of mammalian collagenase

Experientia
R KuttanN Di Ferrante

Abstract

Treatment of radioactively labeled guinea-pig skin soluble collagen or calf skin collagen with the flavonoid (+)-catechin makes the collagen resistant to the action of mammalian collagenase but not to the action of bacterial collagenase. Complete resistance to the action of the mammalian enzyme may be achieved by incubating 0.6 mg of collagen (dry weight) with 0.1 mM (+)-catechin, followed by dialysis to remove the unbound flavonoid. Since incubation of the mammalian enzyme with (+)-catechin does not inhibit its activity, it is postulated that (+)-catechin binds tightly to collagen and modifies its structure sufficiently to make it resistant to enzyme degradation.

  • References8
  • Citations44

References

  • References8
  • Citations44

Citations

Mentioned in this Paper

Benzopyrans
Cavia
3-hydroxyflavone
Zyderm
Soluble
Flavonoids
Substrate Specificity
Binding (Molecular Function)
Collagenase-Like Peptidase
Collagen Location

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