Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.

The Journal of Biological Chemistry
Pallavi AgarwalB Eckes

Abstract

The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing...Continue Reading

References

May 1, 1991·Trends in Biochemical Sciences·L M Shaw, B R Olsen
May 1, 1991·The Journal of Cell Biology·D R KeeneR E Burgeson
Oct 1, 1990·Current Opinion in Cell Biology·M K Gordon, B R Olsen
Jan 1, 1989·The Journal of Investigative Dermatology·C WalzerE Frenk
Jan 1, 1988·The Journal of Investigative Dermatology·J S PerlishR Fleischmajer
Mar 1, 1988·The Journal of Cell Biology·L VaughanR Mayne
Jul 4, 1988·FEBS Letters·S F WottonP R Fryer
Oct 1, 1986·The Journal of Cell Biology·L Y SakaiR E Burgeson
Mar 1, 1987·The Journal of Cell Biology·D R KeeneR E Burgeson
Jan 1, 1985·Annals of the New York Academy of Sciences·T KriegR Fleischmajer
Nov 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·B FontM van der Rest
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Aug 7, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·C Giry-LozinguezM van der Rest
Apr 1, 2000·The Journal of Biological Chemistry·U K BlaschkeP Bruckner
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B B YoungD E Birk
Jul 27, 2001·The Journal of Biological Chemistry·D KesslerB Eckes
May 25, 2002·Molecular and Cellular Biology·Liz SvenssonAke Oldberg
Sep 13, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Paul E Di CesareCarrie Fang
Dec 31, 2003·Trends in Genetics : TIG·Johanna Myllyharju, Kari I Kivirikko
Feb 3, 2004·Journal of Cell Science·J Michael Sorrell, Arnold I Caplan
Mar 16, 2004·The Journal of Biological Chemistry·Manuel KochLeena Bruckner-Tuderman
Feb 8, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Jacqueline T HechtWilliam G Cole
Jul 12, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Fredrik SöderstenKjell Hultenby
Mar 8, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Giuseppina FarinaRussell L Widom
May 27, 2006·The Journal of Biological Chemistry·Manuel KochMarion K Gordon
Jul 25, 2006·The Journal of Biological Chemistry·Guido VeitManuel Koch
Nov 3, 2006·FEBS Letters·Claire LethiasJean-Yves Exposito
Jan 4, 2007·The American Journal of Pathology·Thomas M MerrittJacqueline T Hecht
Mar 3, 2007·The Journal of Clinical Investigation·John Varga, David Abraham
Jun 7, 2007·Journal of Cell Science·Karl E KadlerRaymond P Boot-Handford
Jun 26, 2007·The Journal of Biological Chemistry·Faye Hui ChenJack Lawler
Aug 25, 2007·The Journal of Biological Chemistry·Krisztina HalászDick Heinegård

❮ Previous
Next ❯

Citations

Jul 10, 2013·Archives of Dermatological Research·P MoinzadehT Krieg
Jul 25, 2000·European Journal of Clinical Investigation·U LindqvistB Långström
Aug 18, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anders MalmströmMarco Maccarana
Dec 18, 2013·Arthritis Research & Therapy·Kaisa E OttebyAnna M Blom
Oct 3, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Matthias KamperFrank Zaucke
Jan 19, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Milos MarinkovicXiao-Dong Chen
Feb 28, 2013·The FEBS Journal·Martin A ThelinAnders Malmstrom
Apr 22, 2014·The Journal of Allergy and Clinical Immunology·Elisabeth SalzerKaan Boztug
Jul 6, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Chitrangada AcharyaDominik R Haudenschild
Jan 17, 2014·The Biochemical Journal·Daniela ZwolanekManuel Koch
Mar 20, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Pallavi AgarwalThomas Krieg
May 23, 2015·Molecular Biology of the Cell·Dae Joong KimJosephine C Adams
May 8, 2014·The International Journal of Biochemistry & Cell Biology·Matthias ChiquetManuel Koch
Mar 1, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·L GuerraG Zambruno
Jun 28, 2017·American Journal of Respiratory and Critical Care Medicine·Herbert B SchillerOliver Eickelberg
Jan 10, 2016·Journal of Cell Science·Jan-Niklas SchulzBeate Eckes
Feb 8, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shawn P GroganDarryl D D'Lima
Jan 26, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sara FirnerAnja Niehoff
Jan 8, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Adam EckhardtMartin Ostadal
Jun 20, 2020·Expert Review of Proteomics·Jörn DengjelAlexander Nyström
Sep 16, 2017·Scientific Reports·Joana CaldeiraMário Barbosa
May 29, 2020·Investigative Ophthalmology & Visual Science·Mei SunEdgar M Espana
Jul 19, 2019·Journal of Anatomy·Georgios Theocharidis, John T Connelly
Mar 22, 2020·International Journal of Molecular Sciences·Johannes KupkaZsuzsa Jenei-Lanzl
Jan 24, 2019·International Journal of Molecular Sciences·Kathrin MalyFrank Zaucke
Jul 6, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sarah DelbaereFransiska Malfait
Jul 10, 2020·International Journal of Molecular Sciences·Daniel Feng, Casimiro Gerarduzzi
Oct 24, 2020·Matrix Biology : Journal of the International Society for Matrix Biology·Yayoi IzuDavid E Birk
Nov 21, 2020·Materials·Jung-Seok LeeReinhard Gruber
Jul 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna KöhlerGerhard Sengle

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.