Collagenase for enzymatic debridement: a systematic review

Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society
Janet Ramundo, Mikel Gray

Abstract

Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.

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Citations

Sep 21, 2013·Aesthetic Plastic Surgery·Sara CarellaMaria Giuseppina Onesti
Apr 5, 2013·PloS One·Debashree DeDebasish Bhattacharyya
Apr 5, 2013·BioMed Research International·Agústa GudmundsdóttirBjarki Stefansson
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Jul 14, 2012·Biological & Pharmaceutical Bulletin·Fumihiro MizokamiZenzo Isogai
Apr 26, 2017·International Wound Journal·Jérôme Patry, Virginie Blanchette
May 20, 2017·Pediatric Dermatology·Elizabeth HuettCharlotte Yates
Nov 12, 2016·British Journal of Nursing : BJN·Leanne Atkin, Mark Rippon
Oct 28, 2017·Journal of Comparative Effectiveness Research·Curtis WaycasterCatherine T Milne
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May 20, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Seyed Hamid SalehiMohammad Moradi
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