PMID: 488762Aug 1, 1979Paper

Collagenisation of the Disse space in alcoholic liver disease

Gut
H OrregoD A Kreaden

Abstract

Collagenisation of the space of Disse was systematically assessed to determine its relationship to the clinical and histological manifestations of chronic alcoholic liver disease. Ninety-four chronic alcoholics who had been submitted to biopsy were assessed by clinical manifestations of hepatic dysfunction and by a 17-parameter Combined Clinical and Laboratory Index (CCLI). Liver biopsies were scored for light (LM) and electron-microscopy (EM) abnormalities using a universal scoring system for both. Thirty-five patients with normal liver histology (LM) had an average collagen score of 0.6 +/- 0.1. Twelve cirrhotic patients and 29 with fatty liver, both groups with mild clinical manifestations, did not differ significantly. In 18 cirrhotic patients and five with fatty liver, both groups having severe clinical manifestations, the mean scores were 2.1 +/- 0.8 (P less than 0.02) and 2.5 +/- 0.6 (P less than 0.01) respectively. Collagenisation also correlated with CCLI (P less than 0.001), serum bilirubin (P less than 0.001), serum aspartate transferase (SGOT) (P less than 0.003), and clinical evidence of portal hypertension and histological changes of necrosis, inflammation, and terminal hepatic vein sclerosis. These results sugges...Continue Reading

References

Oct 1, 1978·Alcoholism, Clinical and Experimental Research·J G RankinA I Armstrong
Mar 1, 1970·Gut·P J Scheuer
Sep 1, 1973·Microvascular Research·A M Rappaport
Aug 1, 1971·The American Journal of Medicine·S K SamaK L Wig
Aug 1, 1970·Surgery·T KlugeA Flatmark
Mar 1, 1969·Annals of Internal Medicine·T B ReynoldsR Peters
Mar 1, 1967·Medicine·H A EdmondsonS Borowsky
Mar 1, 1963·Gastroenterology·F SCHAFFNER, H POPER

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Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L R JiaoB R Davidson
Mar 15, 1983·Klinische Wochenschrift·M Nishimura, R Teschke
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S CauletE Martin
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·M S Trigueiro de AraújoJ A Grimaud
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·M S de AraújoJ A Grimaud
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A O DamiãoE C Quintão
Dec 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M GressnerK H Pick-Kober
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·E R Parise, H Rosa
Mar 6, 1989·Biochimica Et Biophysica Acta·B H Davis, A Vucic
Jan 1, 1985·Experimental Pathology·M Balázs, T Halmos
Aug 10, 2000·The British Journal of Surgery·L R JiaoN Habib
Apr 18, 2002·Journal of Clinical Gastroenterology·Steven-Huy B HanTse-Ling Fong
Jan 1, 1992·Journal of Gastroenterology and Hepatology·H Orrego, F J Carmichael
Jan 30, 2009·Journal of Veterinary Internal Medicine·E RaffanP J Watson
May 10, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Nina DibPaul Calès
Feb 27, 2001·AJR. American Journal of Roentgenology·B E Van BeersY Horsmans
Jun 1, 1995·Digestive Diseases and Sciences·D BunoutS Hirsch
Oct 1, 1988·Digestive Diseases and Sciences·C SacchettiM Ponz de Leon
Jul 1, 1990·Digestive Diseases and Sciences·M NissenbaumP Gartside
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·D M Bissell, M O Choun
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·W C Maddrey
Jan 1, 1985·Gastroenterology·H MiyakawaC S Lieber
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C VenturiR Reding
Jan 1, 1987·Annals of the New York Academy of Sciences·Y Israel, H Orrego
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K M Mak, C S Lieber
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T HornJ H Henriksen
Apr 1, 1989·Alcoholism, Clinical and Experimental Research·P RobertP Gaucher
May 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OrregoL M Blendis
Apr 1, 1989·Australian and New Zealand Journal of Medicine·P R Gibson, F J Dudley
Sep 22, 2001·Clinics in Liver Disease·K V Menon, P S Kamath
Aug 1, 1994·Journal of Hepatology·H ImamuraY Idezuki

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