Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma.

Case Reports in Immunology
Tejal NarsaiSudhir Gupta

Abstract

Selective IgM deficiency (SIgMD) and isolated collagenous gastritis are two independent rare disorders. Our purpose is to report the 1st case of SIgMD and isolated collagenous gastritis and collagenous gastritis that has transitioned to EBV + gastric adenocarcinoma. Gastric biopsy tissue was analyzed by EBV-related encoded RNA in situ hybridization assay. Subsets of CD4, CD8, T follicular helper cells (TFH), and members of the "regulatory lymphocytes club" were measured with multiple panels of monoclonal antibodies and isotype controls by multicolor flow cytometry. The patient was diagnosed with SIgMD (extremely low serum IgM 9 mg/dl and normal IgG and IgA and exclusion of secondary causes of low IgM). Soon after SIgMD diagnosis, the patient developed collagenous gastritis and, 8 years later, developed gastric adenocarcinoma that was positive for EBV. An extensive immunological analysis revealed reduced naïve CD4 and CD8 effector memory T cells and increased naïve and central memory CD8 T cells. Among the circulating follicular helper T cells (cTFH), TFH1 and TFH2 were increased whereas TFH17 was decreased. CD4 Treg cells and TFR cells were increased, whereas Breg and CD8 Treg were comparable to control. In conclusion, SIgMD ma...Continue Reading

References

Mar 1, 1990·Postgraduate Medical Journal·S O'MahonyA Ferguson
Dec 1, 1989·Gastroenterology·R B Colletti, T D Trainer
Aug 1, 1989·Annals of Internal Medicine·D B Edwards
Dec 9, 1967·British Medical Journal·J R HobbsP J Watt
Feb 24, 1999·Inflammatory Bowel Diseases·J L ChanF M Giardiello
May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Z VesoulisE Esber
Nov 25, 2000·Molecular Pathology : MP·K Takada
Dec 23, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·H R Gillett, H J Freeman
Nov 2, 2001·The American Journal of Surgical Pathology·C Lagorce-PagesJ F Flejou
Dec 12, 2001·Archives of Pathology & Laboratory Medicine·M StancuR Lev
Aug 19, 2003·European Journal of Gastroenterology & Hepatology·Michael F ByrneStephen E Patchett
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Josine van BeekElisabeth Bloemena
Mar 31, 2004·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Pelayo CorreaM Constanza Camargo
Aug 21, 2004·Journal of Clinical Gastroenterology·Hugh James Freeman
Nov 29, 2007·The American Journal of Surgical Pathology·Jason A DanielsElizabeth A Montgomery
Mar 20, 2008·World Journal of Gastroenterology : WJG·Hugh-James Freeman
Nov 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Julie L RyanMargaret L Gulley
Sep 5, 2009·European Journal of Gastroenterology & Hepatology·Oliver BrainSimon Travis
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Sep 22, 2010·Nature Reviews. Rheumatology·Claudia Mauri, Paul A Blair
Oct 7, 2010·Archives of Pathology & Laboratory Medicine·Purva Gopal, Barbara J McKenna
Feb 25, 2011·Journal of Clinical Gastroenterology·Tarun RustagiJohn V Scholes
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivonne WollenbergLuis Graca
Mar 19, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shradha Agarwal, Lloyd Mayer
Jun 14, 2013·Clinical Reviews in Allergy & Immunology·Ankmalika Gupta Louis, Sudhir Gupta
Mar 4, 2014·The Journal of Allergy and Clinical Immunology·Benjamin GathmannUNKNOWN European Society for Immunodeficiencies Registry Working Party
Apr 11, 2014·Annals of Medicine·Ole Haagen NielsenChristoffer Soendergaard
Aug 20, 2014·Journal of Medical Case Reports·Asma Al-KandariMohammad Mawardi
Nov 12, 2014·Cancers·Jun NishikawaIsao Sakaida
Mar 20, 2015·World Journal of Gastrointestinal Endoscopy·Kenya KamimuraShuji Terai
Dec 31, 2015·International Immunology·Yangyang ZhuYun-Cai Liu
Mar 18, 2016·Journal of Clinical Immunology·Hideki Ueno
Apr 8, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rohan MandaliyaSidney Cohen
May 13, 2017·Gastroenterology Research·Muhammad S AnwarJagmohan S Sidhu
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hong ZhangNing Wang
Jul 20, 2017·Orphanet Journal of Rare Diseases·Nina BrataničMagdalena Avbelj Stefanija
Sep 21, 2017·Frontiers in Immunology·Sudhir Gupta, Ankmalika Gupta
Dec 12, 2017·Journal of Clinical Immunology·Aziz BousfihaKathleen E Sullivan
Feb 3, 2018·International Journal of Molecular Sciences·Patrizia LeoneVito Racanelli

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