PMID: 11310942Apr 20, 2001Paper

Collagens and collagen-related diseases

Annals of Medicine
Johanna Myllyharju, K I Kivirikko

Abstract

The collagen superfamily of proteins plays a dominant role in maintaining the integrity of various tissues and also has a number of other important functions. The superfamily now includes more than 20 collagen types with altogether at least 38 distinct polypeptide chains, and more than 15 additional proteins that have collagen-like domains. Most collagens form polymeric assemblies, such as fibrils, networks and filaments, and the superfamily can be divided into several families based on these assemblies and other features. All collagens also contain noncollagenous domains, and many of these have important functions that are distinct from those of the collagen domains. Major interest has been focused on endostatin, a fragment released from type XVIII collagen, which potently inhibits angiogenesis and tumour growth. Collagen synthesis requires eight specific post-translational enzymes, some of which are attractive targets for the development of drugs to inhibit collagen accumulation in fibrotic diseases. The critical roles of collagens have been clearly illustrated by the wide spectrum of diseases caused by the more than 1,000 mutations that have thus far been identified in 22 genes for 12 out of the more than 20 collagen types. ...Continue Reading

References

Jan 1, 1995·Annual Review of Biochemistry·D J Prockop, K I Kivirikko
Aug 1, 1995·International Archives of Allergy and Immunology·J C Brown, R Timpl
Jan 1, 1995·Progress in Nucleic Acid Research and Molecular Biology·T Pihlajaniemi, M Rehn
Apr 1, 1993·Annals of Medicine·K I Kivirikko
Oct 1, 1995·Current Opinion in Cell Biology·B R Olsen
Feb 15, 1996·The Journal of Clinical Investigation·D A Redford-BadwalD W Rowe
May 15, 1996·The Biochemical Journal·K E KadlerJ A Chapman
Jan 1, 1996·Contributions to Nephrology·K Tryggvason
Nov 1, 1996·Journal of Medical Genetics·A C NichollsF M Pope
Dec 1, 1996·Genes & Development·D CosgroveG C Samuelson
Jan 1, 1997·Nucleic Acids Research·R Dalgleish
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·X LiuR Jaenisch
Mar 1, 1997·Trends in Genetics : TIG·M Krawczak, D N Cooper
May 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·Y Li, B R Olsen
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·A K SrivastavaD Schlessinger
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·K I Kivirikko, J Myllyharju
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·S H McLaughlin, N J Bulleid
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·K Nagata
Apr 3, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L I Smith-Mungo, H M Kagan
Jun 13, 1998·American Journal of Human Genetics·A J GriffithM L Warman
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M A CremerA H Kang
May 23, 1998·The Journal of Biological Chemistry·R WilsonN J Bulleid
Jun 23, 1998·The Journal of Biological Chemistry·P HäggT Pihlajaniemi

❮ Previous
Next ❯

Citations

Sep 3, 2002·Annals of Neurology·Caspar Grond-GinsbachIngrid Hausser
Oct 17, 2002·The Anatomical Record·Jean-Yves ExpositoClaire Lethias
Aug 21, 2009·Cell and Tissue Research·Marion K Gordon, Rita A Hahn
May 25, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Marvin L Tanzer
Nov 26, 2010·Inflammopharmacology· SiddikuzzamanC Guruvayoorappan
May 29, 2012·Journal of Materials Science. Materials in Medicine·Yan GuoXingdong Zhang
Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner
Jun 12, 2012·Journal of Acupuncture and Meridian Studies·Min-Jung KimKwon-Eui Hong
Feb 6, 2004·Journal of Dermatological Science·Motoyuki SuzukiKunzo Orita
Dec 31, 2003·Trends in Genetics : TIG·Johanna Myllyharju, Kari I Kivirikko
May 3, 2003·FEMS Microbiology Letters·Marie-Andrée HouleKoji Nakayama
Sep 22, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M VälkkiläL Ala-Kokko
Feb 6, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Lynn Y SakaiFrancesco Ramirez
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Johanna Myllyharju
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·James M PacePeter H Byers
Nov 15, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Satyajit K KarnikDean Y Li
Jun 1, 2002·Bioorganic & Medicinal Chemistry Letters·Luke A McNeillChristopher J Schofield
Jul 23, 2003·Bioorganic & Medicinal Chemistry Letters·David R MoleChristopher J Schofield
Dec 14, 2002·Trends in Cell Biology·Benjamin S BrookeDean Y Li
Jun 22, 2011·Chemical Communications : Chem Comm·Monica BreurkenMaarten Merkx
Oct 20, 2001·The New England Journal of Medicine·P H Byers
Jul 4, 2009·The Journal of Biological Chemistry·Claus-Werner FranzkeCarl P Blobel
Nov 17, 2005·Bioinformatics·Núria López-BigasChristos A Ouzounis
Apr 9, 2008·Journal of Pediatric Hematology/oncology·Iordanis PelagiadisMaria Kalmanti
May 20, 2005·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·K S HewitsonC J Schofield
Mar 31, 2005·Journal of Biomechanical Engineering·B E Layton, A M Sastry
Jun 25, 2009·Pharmacological Reviews·Hannu JärveläinenRisto Penttinen
Jul 1, 2004·Molecular and Cellular Biology·Markella PonticosGeorge Bou-Gharios
Dec 3, 2003·Annals of the Rheumatic Diseases·N Noponen-HietalaL Ala-Kokko
Sep 6, 2005·Journal of Medical Genetics·A K Lampe, K M D Bushby
Apr 7, 2009·Annual Review of Biochemistry·Matthew D Shoulders, Ronald T Raines
Apr 2, 2003·Cell Biology Education·Robin Wright, James Boggs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.