PMID: 7028399Jan 1, 1981Paper

Collagens and non collagenous proteins in the human eye. I. Corneal stroma in vivo and keratocyte production in vitro

Current Eye Research
D BenEzra, J M Foidart

Abstract

Human corneal stroma in situ and keratocyte activity in vitro were studied by the indirect immunofluorescent technique using highly purified antibodies to the various types of collagens, fibronectin and laminin. Studying the localization of the various collagens in situ, it was observed that only type I collagen is present in the human corneal stroma. No positive immunofluorescence is obtained for type II or type III collagen. With type IV collagen, a bright immunofluorescence is observed at the level of Bowman's and Descemet's membranes. However, in vitro, the keratocyte cultures demonstrated the production of both type I and III collagens. No evidence for the production of type II or IV collagens was observed. Along with the collagens, human keratocytes in vitro also produced fibronectin. As for the non collagenous components of basement membrane (laminin), although a positive immunofluorescence was obtained the involvement of other cell-membrane glycoproteins in this reaction is not excluded. The possibility that a deregulation of type III collagen synthesis in vivo might be occurring also during certain pathologies and in corneal wound healing is postulated.

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Citations

Jan 1, 1988·Journal of Ocular Pharmacology·M Ding, N L Burstein
Mar 10, 2007·The British Journal of Ophthalmology·Sarah P MeredithMartin P Snead
Apr 1, 1993·The British Journal of Ophthalmology·S J TuftK M Meek
Oct 28, 2005·Current Eye Research·Kwou-Yeung WuShow-Jen Hong
Jun 16, 2010·Cutaneous and Ocular Toxicology·Mostafa NaderiSaayyed Ali Alavi
Jun 2, 2009·Brain Research Bulletin·Yureeda QaziBalamurali K Ambati
Aug 18, 2006·Experimental Eye Research·Yang LiuTeruo Nishida
Jan 24, 2006·Progress in Retinal and Eye Research·Naoki KumagaiTeruo Nishida
Aug 18, 2005·Journal of Cataract and Refractive Surgery·Siegfried G PriglingerUlrich Welge-Luessen
Jan 27, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hyungwoo Lee, Byung Joo Cho
Mar 8, 2019·Cutaneous and Ocular Toxicology·Emine SenUfuk Elgin
Oct 26, 2020·Korean Journal of Ophthalmology : KJO·Minsu JangByung Joo Cho

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