Collapse and coexistence for a molecular braid with an attractive interaction component subject to mechanical forces

Journal of Physics. Condensed Matter : an Institute of Physics Journal
Dominic J O' Lee

Abstract

Dual mechanical braiding experiments provide a useful tool with which to investigate the nature of interactions between rod-like molecules, for instance actin and DNA. In conditions close to molecular condensation, one would expect an appearance of a local minimum in the interaction potential between the two molecules. We investigate this situation, introducing an attractive component into the interaction potential, using a model developed for describing such experiments. We consider both attractive interactions that do not depend on molecular structure and those which depend on a DNA-like helix structure. In braiding experiments, an attractive term may lead to certain effects. A local minimum may cause molecules to collapse from a loosely braided configuration into a tight one, occurring at a critical value of the moment applied about the axis of the braid. For a fixed number of braid pitches, this may lead to coexistence between the two braiding states, tight and loose. Coexistence implies certain proportions of the braid are in each state, their relative size depending on the number of braid pitches. This manifests itself as a linear dependence in numerically calculated quantities as functions of the number of braid pitches....Continue Reading

References

Mar 29, 1996·Science·T R StrickV Croquette
Feb 9, 1996·Science·P CluzelF Caron
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D Moroz, P Nelson
Apr 17, 1998·Biophysical Journal·T R StrickV Croquette
Sep 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J F Marko, E D Siggia
May 8, 1999·Biophysical Journal·J Ubbink, T Odijk
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael D StoneNicholas R Cozzarelli
Jul 18, 2003·Nature·Zev BryantCarlos Bustamante
Mar 22, 2005·Biophysical Journal·G CharvinV Croquette
Mar 16, 2007·Physical Review Letters·Taiji IkawaCyrus R Safinya
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·John F Marko
Nov 13, 2007·Nature Methods·Maarten C NoomGijs J L Wuite
Mar 11, 2008·Biophysical Journal·Brian A ToddDonald C Rau
Jun 4, 2008·Physical Review Letters·Scott ForthMichelle D Wang
Aug 30, 2008·Nucleic Acids Research·Aaron WynveenSergey Leikin
Mar 5, 2009·Physical Review Letters·Francesco MosconiVincent Croquette
Apr 1, 2009·The Journal of Physical Chemistry. B·A G Cherstvy
Mar 11, 2010·Nucleic Acids Research·Péter Várnai, Youri Timsit
Apr 8, 2010·Biophysical Journal·Hergen BrutzerRalf Seidel
Aug 20, 2010·The Journal of Physical Chemistry. B·D J LeeS Leikin
Apr 27, 2011·Physical Review Letters·Sébastien Neukirch, John F Marko
Aug 17, 2011·Biophysical Journal·Ruggero CortiniSergey Leikin
Feb 15, 2012·Acta Biomaterialia·David Argudo, Prashant K Purohit
Mar 10, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·John F Marko, Sébastien Neukirch
Jul 26, 2012·Biophysical Journal·David Argudo, Prashant K Purohit
Aug 3, 2012·Biophysical Journal·Robert SchöpflinGero Wedemann
Sep 17, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marc EmanuelHelmut Schiessel
Sep 17, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dominic Lee
Jun 8, 2014·Nucleic Acids Research·Richard LaveryKrystyna Zakrzewska
Jul 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dominic J Lee

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Citations

Mar 3, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Dominic J O' Lee
Jun 18, 2017·Physical Review. E·Sumitabha Brahmachari, John F Marko

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