Collapsing angiokeloidal dermatofibroma

The American Journal of Dermatopathology
Alicia M SchnebelenBruce R Smoller

Abstract

A heterogeneous group of benign fibrohistiocytic lesions has been assembled under the umbrella term, dermatofibroma. These lesions share a morphology of bland spindled cells encompassed by and intercalating through thick dermal collagen; unique variants have been described based on secondary histologic features, some of which include aneurysmal, myxoid, lipidized, signet ring, angiomatous, and keloidal. Here, we present a distinct dermatofibroma variant henceforth known as collapsing angiokeloidal dermatofibroma identified in 2 patients with slowly growing nodules of the buttock and the arm. Microscopically, the lesions have a characteristic dermatofibroma appearance but are accompanied by unusual diffuse small caliber vessels whose walls are collapsed by a thick, eosinophilic, keloid-like substance. The eosinophilic material resembles the adjacent dermal collagen; however, it does not stain for type-4 collagen or type-1 procollagen, amyloid, or glycogen. Although the exact composition of the keloidal material remains ambiguous, the architectural novelty of collapsing angiokeloidal dermatofibroma serves to further expand the morphologic spectrum of benign fibrous histiocytomas, although highlighting the difficulty in distinguis...Continue Reading

References

May 20, 1998·The American Journal of Surgical Pathology·T T KuoH L Chan
Apr 19, 2000·The American Journal of Dermatopathology·J Iwata, C D Fletcher
Oct 21, 2004·International Journal of Surgical Pathology·Bernhard ZelgerWalter H C Burgdorf
Jan 22, 2009·The American Journal of Dermatopathology·M C Garrido-RuizJosé L Rodriguez Peralto
May 30, 2009·Journal of Cutaneous Pathology·Jinah Kim, Jennifer M McNiff

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Citations

Jun 14, 2017·The American Journal of Dermatopathology·Sergio Santos-AlarcónLuis Requena

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