Collapsing the list of myocardial infarction-related differentially expressed genes into a diagnostic signature

Journal of Translational Medicine
German OsmakOlga Favorova

Abstract

Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central component of CAD pathogenesis is a chronic vascular inflammation. However, the mechanisms underlying the changes that occur in T, B and NK lymphocytes, monocytes and other immune cells during CAD and MI are still poorly understood. One of those pathogenic mechanisms might be the dysregulation of intracellular signaling pathways in the immune cells. In the present study we performed a transcriptome profiling in peripheral blood mononuclear cells of MI patients and controls. The machine learning algorithm was then used to search for MI-associated signatures, that could reflect the dysregulation of intracellular signaling pathways. The genes ADAP2, KLRC1, MIR21, PDGFD and CD14 were identified as the most important signatures for the classification model with L1-norm penalty function. The classifier output quality was equal to 0.911 by Receiver Operating Characteristic metric on test data. These results were validated on two independent open GEO datasets. Identified MI-associated signatures can be further assisted in MI diagnosis and/...Continue Reading

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Citations

Apr 8, 2021·Expert Review of Proteomics·Darja Kanduc

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Datasets Mentioned

BETA
GSE62646
GSE59867

Software Mentioned

NetworkX
limma
learn
String
biomaRt
affy package
of Reactome Database
Reactome
scikit
Tools

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