DOI: 10.1101/491928Dec 10, 2018Paper

Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow

BioRxiv : the Preprint Server for Biology
Neesha S PatelMark A. Carlson


Introduction: The development of collateral vasculature is a key mechanism compensating for arterial occlusions in patients with peripheral artery disease (PAD). We aimed to examine the development of collateral pathways after ligation of native vessels in a porcine model of PAD. Methods: Right hindlimb Ischemia was induced in domestic swine (N=11, male) using two different versions of arterial ligation. Version 1 (N=6) consisted of ligation/division of the right external iliac, profunda femoral and superficial femoral arteries. Version 2 (N=5) consisted of the ligation of Version 1 with additional ligation/division of the right internal iliac artery. Development of collateral pathways was evaluated with standard angiography at baseline (prior to arterial ligation) and at termination (4 weeks later). Relative luminal diameter of the arteries supplying the ischemic right hindlimb were determined by 2D angiography. Results: The dominant collateral pathway that developed after Version 1 ligation connected the right internal iliac artery to the right profunda femoral and then to the right superficial femoral/popliteal artery. Mean luminal diameter of the right internal iliac artery at termination increased by 38% compared to baseli...Continue Reading

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