Collateral pathways from the ventromedial hypothalamus mediate defensive behaviors

Neuron
Li WangDayu Lin

Abstract

The ventromedial hypothalamus (VMH) was thought to be essential for coping with threat, although its circuit mechanism remains unclear. To investigate this, we optogenetically activated steroidogenic factor 1 (SF1)-expressing neurons in the dorsomedial and central parts of the VMH (VMHdm/c), and observed a range of context-dependent somatomotor and autonomic responses resembling animals' natural defensive behaviors. By activating independent pathways emanating from the VMHdm/c, we demonstrated that VMHdm/c projection to the dorsolateral periaqueductal gray (dlPAG) induces inflexible immobility, while the VMHdm/c to anterior hypothalamic nucleus (AHN) pathway promotes avoidance. Consistent with the behavior changes induced by VMH to AHN pathway activation, direct activation of the AHN elicited avoidance and escape jumping, but not immobility. Retrograde tracing studies revealed that nearly 50% of PAG-projecting VMHdm/c neurons send collateral projection to the AHN and vice versa. Thus, VMHdm/c neurons employ a one-to-many wiring configuration to orchestrate multiple aspects of defensive behaviors.

References

Dec 15, 1978·The Journal of Comparative Neurology·C B SaperW M Cowan
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S Canteras, L W Swanson
Sep 22, 1980·Brain Research·C B Saper, A D Loewy
Sep 18, 1995·The Journal of Comparative Neurology·N S CanterasL W Swanson
Dec 17, 1998·Physiology & Behavior·R J BlanchardS Parmigiani
Feb 1, 1962·The Journal of Physiology·A FERNANDEZ DE MOLINA, R W HUNSPERGER
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Apr 11, 2006·Frontiers in Neuroendocrinology·Kristy M McClellanStuart Tobet
May 13, 2008·Behavioural Brain Research·Raquel C R MartinezNewton S Canteras
Oct 27, 2009·Journal of Neurosurgery·W Bryan WilentDonald M Whiting
Mar 23, 2010·Cell·Viviana GradinaruKarl Deisseroth
Nov 12, 2013·Nature Neuroscience·Bianca A SilvaCornelius T Gross
Dec 19, 2013·Frontiers in Aging Neuroscience·Jessica BullinsW Jack Rejeski

❮ Previous
Next ❯

Citations

Jan 5, 2016·Cell Metabolism·Scott M SternsonShengjin Xu
Feb 13, 2016·Frontiers in Neural Circuits·Yongsoo KimBo Li
Feb 6, 2016·Current Opinion in Neurobiology·Koichi HashikawaDayu Lin
Nov 11, 2015·Neuroscience Bulletin·Xi Zha, Xiaohong Xu
Aug 25, 2015·Frontiers in Neuroscience·Newton S CanterasAntonio P Carobrez
Aug 27, 2015·Nature Neuroscience·Karl Deisseroth
Apr 11, 2015·Nature Reviews. Neuroscience·Darran Yates
Mar 10, 2015·ELife·Prabhat S KunwarDavid J Anderson
Jun 10, 2016·Nature·Philip TovoteAndreas Lüthi
Mar 19, 2016·The European Journal of Neuroscience·Bianca A SilvaCornelius T Gross
Oct 18, 2016·Current Opinion in Neurobiology·Ana G Pereira, Marta A Moita
Oct 19, 2016·Nature Reviews. Neuroscience·David J Anderson
Jun 27, 2017·Neuron·Kentaro K IshiiKazushige Touhara
Jan 11, 2018·Environmental Science and Pollution Research International·Letícia Silva CardosoGuilherme Malafaia
Oct 21, 2017·Brain : a Journal of Neurology·Roger L Albin
Sep 19, 2017·Nature Neuroscience·Koichi HashikawaDayu Lin
Apr 8, 2016·Journal of Neurophysiology·Yasmine El-ShamaylehGregory D Horwitz
Jan 30, 2018·Frontiers in Systems Neuroscience·Yoshiko HashikawaDayu Lin
Jan 31, 2018·Nature Neuroscience·Sae-Geun ParkDaesoo Kim
Dec 1, 2017·Endocrinology·Naranbat NasanbuyanTatsushi Onaka
May 8, 2019·Neuroscience Bulletin·Yi LiMinmin Luo
May 1, 2019·Nature Neuroscience·Ping DongXiao-Ming Li
Oct 9, 2019·Journal of Huntington's Disease·Rachel Y CheongÅsa Petersén
Apr 8, 2020·Annual Review of Neuroscience·Tiago Branco, Peter Redgrave
Jul 29, 2020·Nature Neuroscience·Takashi YamaguchiDayu Lin
Sep 18, 2020·Nature·Ann KennedyDavid J Anderson
Mar 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Liching LoBrandon Weissbourd
Apr 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas N FosterAlan G Watts
Sep 10, 2017·Journal of Neuroendocrinology·T FujikawaJ K Elmquist
Apr 28, 2019·Experimental & Molecular Medicine·Teppei FujikawaKi Woo Kim
Feb 26, 2019·Nature Neuroscience·Samara M MillerLarry S Zweifel
Jul 5, 2019·The Journal of Veterinary Medical Science·Ryoko KoizumiYukari Takeuchi
Jan 31, 2020·Frontiers in Behavioral Neuroscience·María RodríguezMarco Contreras
Jun 22, 2018·Nature·Dominic A EvansTiago Branco
Sep 23, 2018·Environmental Science and Pollution Research International·Bruna de Oliveira MendesGuilherme Malafaia
Sep 17, 2016·Learning & Memory·Bianca A SilvaJohannes Gräff
Jul 1, 2017·Environmental Science and Pollution Research International·Bruna de Oliveira MendesGuilherme Malafaia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.