Collateral sprouting as a target for improved function after spinal cord injury

Journal of Neurotrauma
Theo Hagg

Abstract

Functional recovery after spinal cord injury might be improved by enhancing the extent of innervation through stimulation of collateral sprouting, which is the growth of a new axon along the shaft of a non-injured axon. This review discusses (1) the spontaneous collateral sprouting of uninjured motor and sensory systems that has been shown after spinal cord injury in animal models, (2) experimental treatment strategies that are being developed to enhance collateral sprouting in motor systems and to reduce sensory sprouting which is associated with autonomic dysreflexia and pain, and (3) cell-surface and intracellular signaling mechanisms that are known to regulate axonal branching. The conclusion is that relatively little is known about collateral sprouting in adult mammals after spinal cord injury but that it may contribute to spontaneous functional motor recovery and causes sensory dysfunction. There is some promising data in rodents that collateral sprouting can be modulated for improved function, but the applicability to primates and relevance to human spinal cord injury remains to be determined.

References

Dec 15, 1990·The Journal of Comparative Neurology·R Z Kuang, K Kalil
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J DiamondB Visheau
Nov 1, 1974·The Journal of Comparative Neurology·M Murray, M E Goldberger
Dec 1, 1970·Experimental Neurology·S P Hicks, C J D'Amato
May 1, 1966·The Journal of Comparative Neurology·D C Goodman, J A Horel
Aug 28, 1981·Science·C E Hulsebosch, R E Coggeshall
Sep 1, 1993·The European Journal of Neuroscience·L Schnell, M E Schwab
Jun 1, 1996·The European Journal of Neuroscience·K M Giehl, W Tetzlaff
Aug 1, 1996·Microscopy Research and Technique·S S Scherer
Nov 14, 1998·Injury·J R TaylorB A Kakulas
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Chang, S V Popov
Aug 4, 1999·Spinal Cord·A K Karlsson
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L I BenowitzN Irwin
May 29, 2000·The Journal of Spinal Cord Medicine·B A Kakulas
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeidnerM H Tuszynski
Apr 3, 2001·Nature Reviews. Neuroscience·O Raineteau, M E Schwab
May 29, 2001·The Journal of Biological Chemistry·F RoncaR U Margolis
Jul 27, 2001·Mechanisms of Development·K SchimmelpfengC Klämbt
Dec 26, 2001·The Journal of Comparative Neurology·Valérie MarillatAlain Chédotal
Mar 29, 2002·Nature·Julian NgLiqun Luo

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Neurotrauma·Megan Ryan DetloffJohn D Houlé
Oct 20, 2007·Annual Review of Cell and Developmental Biology·James Q Zheng, Mu-Ming Poo
Mar 25, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Corinna Darian-Smith
Dec 20, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Parizad M Bilimoria, Azad Bonni
Apr 16, 2011·BMC Neuroscience·Emanuela EspositoSalvatore Cuzzocrea
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea Ketschek, Gianluca Gallo
Dec 9, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alexandre RasouliRanjan Gupta
Jul 6, 2007·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Dec 20, 2008·The EMBO Journal·Ana Mingorance-Le Meur, Timothy P O'Connor
Feb 19, 2008·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Feb 11, 2011·Developmental Neurobiology·Gianluca Gallo
May 3, 2007·Expert Opinion on Pharmacotherapy·Jay KhastgirPaul Abrams
Nov 10, 2014·Metabolic Brain Disease·Lingbin MengRui Ji
Dec 12, 2018·Neural Regeneration Research·Mallory E FilippAmgad S Hanna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.