Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Folia Neuropathologica
Paweł ReichertJerzy Gosk

Abstract

This study assessed the collateral sprouting in avulsion of the ventral branches of the C5 and C6 spinal nerves treated by coaptation of these nerves to the C7 spinal nerve on the brachial plexus of rabbits. Thirty-six New Zealand rabbits were randomly divided into four groups: end-to-side coaptation (ESN) (n = 12), side-to-side coaptation (SSN) (n = 12), direct neurorrhaphy (end-to-end) (EEN) (n = 6) and no coaptation (n = 6). The operations were performed on the left brachial plexus. The contralateral, non-operated right brachial plexi were used as the control group. The groups were compared using morphological, electrophysiological and behavioral methods. The follow-up duration was 20 weeks. Significant differences were observed in all parameters when the experimental groups were compared with the control group and the no coaptation group. The histology of axonal regeneration after ESN, but not after SSN, was comparable to that after EEN. There were no significant differences in the electrophysiological, behavioral assessment or G-ratio parameters between the ESN and EEN groups. There were significant differences in the behavioral assessment, G-ratio and the histomorphometric parameters between the SSN and EEN groups, which ...Continue Reading

Citations

Aug 23, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L L KorsunskayaL R Muratova

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