Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala

Brain Structure & Function
Xinwen DongGilbert J Kirouac

Abstract

The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus with dense projections to the nucleus accumbens (NAc), dorsolateral region of the bed nucleus of the stria terminalis (BSTDL) and the lateral/capsular region of the central nucleus of the amygdala (CeL/CeC). Recent experimental evidence indicates that the PVT is involved in both appetitive and aversive behaviors. However, it is unknown if subgroups of neurons in the PVT innervate different subcortical targets or if the same neurons issue collaterals to multiple areas. To address this issue, we injected two different fluorescent retrograde tracers, cholera toxin subunit B conjugated to Alexa Fluor-488 or Alexa Fluor-594, into different pairs of the subcortical targets including different parts of the NAc (shell, core, dorsomedial shell, and ventromedial shell), BSTDL, and amygdala (basolateral amygdala and CeL/CeC). The results indicate a moderate to high level of collateralization of projections from neurons in the PVT to NAc, BSTDL, and CeL/CeC suggesting a potential importance of the PVT in simultaneously coordinating the activity of key regions of the brain involved in mediating emotional and motivational behaviors. We also observed a difference ...Continue Reading

References

Jan 1, 1991·Progress in Brain Research·M BentivoglioL Kruger
Jul 22, 1990·The Journal of Comparative Neurology·H S Su, M Bentivoglio
Sep 8, 1990·The Journal of Comparative Neurology·H W Berendse, H J Groenewegen
Aug 21, 1995·The Journal of Comparative Neurology·M M MogaR Y Moore
Feb 1, 1994·Trends in Neurosciences·H J Groenewegen, H W Berendse
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·C D Young, A Y Deutch
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Oct 29, 2000·Trends in Neurosciences·A ParentM Parent
Aug 28, 2004·Trends in Neurosciences·Yoland SmithMamadou Sidibe
Sep 20, 2006·Psychopharmacology·Saleem M Nicola
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Susana PeciñaKent C Berridge
Mar 4, 2008·The Journal of Comparative Neurology·Robert P Vertes, Walter B Hoover
Mar 18, 2008·Nature Neuroscience·Sheila M Reynolds, Kent C Berridge
Feb 10, 2009·The European Journal of Neuroscience·Adam S HamlinGavan P McNally
Jun 27, 2009·Neuron·Ingrid EhrlichAndreas Lüthi
Jul 17, 2009·Pharmacology, Biochemistry, and Behavior·Yonghui LiGilbert J Kirouac
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael DavisChristian Grillon
Jan 5, 2010·Pharmacology, Biochemistry, and Behavior·Yonghui LiGilbert J Kirouac
Sep 10, 2011·Neuropharmacology·Nancy Padilla-CoreanoGregory J Quirk
Mar 22, 2014·Frontiers in Behavioral Neuroscience·David T HsuSeema Bhatnagar
Apr 2, 2014·Frontiers in Behavioral Neuroscience·Yonghui LiGilbert J Kirouac
Sep 25, 2014·Annual Review of Psychology·Stan B Floresco
Jan 21, 2015·Nature·Fabricio H Do-MonteGregory J Quirk
May 8, 2015·Neuron·Kent C Berridge, Morten L Kringelbach
Jun 7, 2015·Drug and Alcohol Dependence·Michael D ReedJames R Stellar
Aug 11, 2015·Neuroscience and Biobehavioral Reviews·Gilbert J Kirouac

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Citations

Jul 29, 2020·Frontiers in Psychiatry·Susan F SonnenscheinAnthony A Grace
Jun 16, 2018·Molecular Psychiatry·Pinelopi PliotaWulf Haubensak
Jul 11, 2019·Development and Psychopathology·Theodore P Beauchaine, Dante Cicchetti
Dec 18, 2020·Pharmacology, Biochemistry, and Behavior·Yanaira Alonso-CaraballoElena H Chartoff
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Jessica R BarsonWen-Jun Gao
Dec 6, 2020·Nature Communications·B Sofia BeasMario A Penzo
Feb 16, 2021·Frontiers in Behavioral Neuroscience·Genevieve R CurtisJessica R Barson
Nov 13, 2020·Frontiers in Behavioral Neuroscience·Jacqueline F McGinty, James M Otis
Mar 6, 2021·Frontiers in Behavioral Neuroscience·Kuikui ZhouYingjie Zhu
Feb 21, 2021·Neuroscience and Biobehavioral Reviews·Gavan P McNally
Feb 16, 2021·The International Journal of Neuropsychopharmacology·Stephanie M Perez, Daniel J Lodge
Apr 30, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·D FiedlerM D Lange
May 11, 2021·Frontiers in Integrative Neuroscience·Sarah M KarkMichael A Yassa
May 15, 2021·Behavioural Brain Research·Mi-Seon Kong, Larry S Zweifel
Jun 4, 2021·Frontiers in Behavioral Neuroscience·Cassandra L KooikerTallie Z Baram
Jul 6, 2021·Frontiers in Integrative Neuroscience·Amanda G Iglesias, Shelly B Flagel
Aug 3, 2021·Frontiers in Systems Neuroscience·Aurélie De Groote, Alban de Kerchove d'Exaerde
Aug 14, 2021·Translational Psychiatry·Julian Cheron, Alban de Kerchove d'Exaerde
Aug 26, 2021·Cell Reports·Giuseppe GiannottiJamie Peters
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans
Dec 28, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luiz PessoaEster Desfilis

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