Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions

Brain Research
Yasuo NishijimaJialing Liu

Abstract

Despite the tremendous progress made in the treatment of cerebrovascular occlusive diseases, many patients suffering from ischemic brain injury still experience dismal outcomes. Although rehabilitation contributes to post-stroke functional recovery, there is no doubt that interventions that promote the restoration of blood supply are proven to minimize ischemic injury and improve recovery. In response to the acutely decreased blood perfusion during arterial occlusion, arteriogenesis, the compensation of blood flow through the collateral circulation during arterial obstructive diseases can act not only in a timely fashion but also much more efficiently compared to angiogenesis, the sprouting of new capillaries, and a mechanism occurring in a delayed fashion while increases the total resistance of the vascular bed of the affected territory. Interestingly, despite the vast differences between the two vascular remodeling mechanisms, some crucial growth factors and cytokines involved in angiogenesis are also required for arteriogenesis. Understanding the mechanisms underlying vascular remodeling after ischemic brain injury is a critical step towards the development of effective therapies for ischemic stroke. The present article will...Continue Reading

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Citations

Dec 10, 2016·Journal of Neurosurgery. Pediatrics·Armide StoreyEdward Smith
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Yasuo NishijimaJialing Liu
Aug 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiroshi YamauchiTatsuya Higashi
Sep 2, 2020·The European Journal of Neuroscience·Abina Vishni RavindranSonu Bhaskar
Mar 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shi ShuBin Peng
Aug 28, 2020·Frontiers in Physiology·Moises Freitas-AndradeBaptiste Lacoste
Sep 29, 2020·Restorative Neurology and Neuroscience·Yimeng Lina DuDonald G Stein
Jul 28, 2019·International Journal of Molecular Sciences·Hua ZhangJames E Faber
Jan 5, 2021·The Neurologist·Xianxian ZhangQi Fang

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