PMID: 9423214Jan 10, 1998Paper

Collecting duct carcinoma of the kidney: a report of three cases and review of the literature

Pathology
L R MatzJ B Vivian

Abstract

Collecting duct carcinoma (CDC) of the kidney is a rare neoplasm arising from the medullary collecting ducts. The clinicopathological features of three cases are here presented to add to the 42 cases reported so far in the English language literature. Hematuria is the most common presenting symptom, although 10% of patients present with metastatic disease, often in neck lymph nodes. The tumor mass is typically centred on the medulla of the kidney and extends into the cortex. Radiological diagnosis may be difficult because the radiological features of CDC are poorly described. The histological appearances have been described as tubulo-papillary, tubular, solid and sarcomatoid. Intracytoplasmic mucin may be present. The typical immunohistochemical profile is positive staining with antibodies for low and high molecular weight keratin and epithelial membrane antigen (EMA) and positive staining with the lectin Ulex europaeus agglutinin. Literature reports of cytogenetic characterisation show loss of chromosomes resulting in monosomies. Prognosis is poor as more than half of the reported cases have developed metastases or died within two years of presentation.

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Citations

Nov 25, 2005·International Urology and Nephrology·J OckrimT J Christmas
Jun 1, 2005·Urology·Serhat GürocakTurgut Alkibay
Feb 27, 2001·AJR. American Journal of Roentgenology·P J PickhardtJ K McLarney
Feb 18, 2014·International Urology and Nephrology·Nikolaos TsoukalasAnna Efremidis
Mar 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mi-Kyung Kim, Seonwoo Kim
Jul 3, 2015·Oncology Letters·Y U HuYuantao Wang
Jun 4, 2013·Clinical Radiology·Q ZhuS Wang
Feb 15, 2008·Clinical Genitourinary Cancer·Slim CharfiTahya Sellami-Boudawara
May 30, 2006·Clinical Genitourinary Cancer·Kevin A DavidDavid M Nanus
Mar 6, 2007·European Urology·Pierre I KarakiewiczJean-Jacques Patard
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M LiL S Minsky
Sep 7, 2019·Cancer Treatment Reviews·Filippo PaganiGiuseppe Procopio
May 13, 1999·Archives of Pathology & Laboratory Medicine·M Fukunaga
Dec 2, 2000·Archives of Pathology & Laboratory Medicine·R J CohenH J Dawkins

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