Collecting duct carcinoma of the kidney: Disease characteristics and treatment outcomes from the National Cancer Database

Urologic Oncology
Wilson SuiGuarionex Joel DeCastro

Abstract

To use a large population-level database to assess survival outcomes for collecting duct renal cell carcinoma (CDRCC). The National Cancer Database was queried for all cases of CDRCC and clear cell renal cell carcinoma (CCRCC) from 2004 to 2013. After removing patients with other cancer diagnoses, the analytic cohort was composed of 201,686 CCRCC and 577 CDRCC cases. Kaplan-Meier and cox proportional hazards analysis were employed to model survival. Compared to CCRCC, patients with CDRCC presented with higher grade and stage, node positive, and metastatic disease (70.7% vs. 30.0% with metastasis; P<0.001). Overall median survival for CDRCC was 13.2 months (95% CI: 11.0-15.5) compared to the 122.5 months (95% CI: 121.0-123.9) for CCRCC. On multivariate analysis of the CDRCC cohort, increasing T stage, high-grade disease, and metastasis were predictors of mortality. Of 184 patients with metastatic CDRCC, 113 underwent cytoreductive nephrectomy (CNx) whereas the rest were treated with chemo/radiation or observed. Survival outcomes were improved in patients who received both CNx with chemo/radiation compared to CNx alone (hazard ratio = 0.51, 95% CI: 0.32-0.79) or chemo/radiation alone (hazard ratio = 0.57, 95% CI: 0.37-0.89) on mu...Continue Reading

Citations

Jan 18, 2020·International Cancer Conference Journal·Kyohei WatanabeHideaki Miyake
Aug 11, 2020·World Journal of Gastrointestinal Surgery·Zsolt Zoltan FulopTivadar Jr Bara
Jun 13, 2021·Urologic Oncology·Gerardo CabanillasJavier A Arias-Stella

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