Collective effects of age, sex, genotype, and cognitive status on fitness outcomes

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Jill K MorrisOzioma Okonkwo

Abstract

Individuals with Alzheimer's disease (AD) broadly exhibit lower cardiorespiratory fitness (CRF) compared to cognitively healthy older adults. Other factors, such as increasing age and female sex, are also known to track with lower CRF levels. However, it is unclear how these factors together with AD diagnosis and genetic risk (apolipoprotein e4 ; APOE4) collectively affect CRF. Our primary objective was to characterize the collective relationship of age, sex, APOE4 carrier status , and cognitive status (nondemented or AD) with two commonly reported CRF outcomes, VO2 max and oxygen uptake efficiency slope (OUES). To interrogate the unique and combined effect of age, sex, APOE4, and cognitive status on CRF, we pooled multiple datasets and tested several statistical models allowing all possible interactions. AD diagnosis was consistently associated with lower maximal CRF, which declined with increasing age. APOE4 was also associated with lower maximal CRF (VO2max), but only in male subjects. Submaximal CRF (OUES) was lower in APOE4 carriers of both sexes, although this difference converged in male subjects with advancing age. This multi-cohort analysis (n = 304) suggests that APOE4 carrier status and sex are important consideratio...Continue Reading

References

Jun 1, 1974·Journal of Applied Physiology·V F FroelicherM C Lancaster
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R P FriedlandS M Debanne
Mar 20, 2001·Archives of Neurology·D LaurinK Rockwood
Feb 28, 2002·Archives of Internal Medicine·Federica PignattiMarco Trabucchi
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Jennifer WeuveFrancine Grodstein
Jan 19, 2006·Annals of Internal Medicine·Eric B LarsonWalter Kukull
Mar 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M HollenbergI B Tager
May 3, 2011·Neurobiology of Aging·Eric D VidoniJeffrey M Burns
Jan 25, 2014·Journal of Applied Physiology·Graeme Carrick-RansonBenjamin D Levine
Nov 20, 2015·Journal of the International Neuropsychological Society : JINS·Stephanie A SchultzOzioma C Okonkwo
Feb 12, 2017·PloS One·Jill K MorrisJeffrey M Burns
Jan 13, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sterling C JohnsonMark A Sager
Jul 5, 2019·Brain, Behavior, and Immunity·Patrick M Dougherty

❮ Previous
Next ❯

Citations

Jul 17, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ryan J DoughertyDane B Cook

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01129115
NCT02000583
NCT01128361
NCT00267124

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

© 2021 Meta ULC. All rights reserved