Collision metastasis of urothelial and prostate carcinomas to the same lymph node: a case report and review of the literature.

Journal of Medical Case Reports
Tapan BhavsarYajue Huang

Abstract

A collision tumor is the meeting and eventual intermingling of two malignant neoplasms arising from independent topographical sites. Collision metastasis of carcinomas in the lymph nodes is a rare event. A literature search revealed only three cases of such a collision metastasis of prostatic and urothelial carcinoma, and only one of those cases had used immunohistochemical stains to distinguish the two tumors. We encountered a case of this rare entity in an 83-year-old African-American man who presented to our facility with increasing pelvic pain after a transurethral resection of a high-grade bladder tumor and a negative metastatic computed tomography chest, abdomen and pelvic scan investigation. A radical cystoprostatectomy was subsequently performed revealing a multi-centric, high-grade, ill-defined infiltrating urothelial carcinoma infiltrating the right pericystic soft tissue. A histopathological examination of the prostate revealed a multi-centric adenocarcinoma (Gleason 4 + 4) involving two pelvic lymph nodes. Interestingly, while the right pelvic lymph node was positive for metastatic prostatic adenocarcinoma alone, immunohistochemical studies of the left pelvic lymph node revealed a dual metastatic urothelial (cytoker...Continue Reading

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Citations

Jan 23, 2014·Pathology, Research and Practice·Waseem AnaniAnil V Parwani
Oct 4, 2008·International Seminars in Surgical Oncology : ISSO·Khalid A El-GendyJeremy I Livingstone
Feb 13, 2020·International Journal of Surgical Pathology·Virginia MillerKaren Schoedel
May 18, 2017·Case Reports in Oncology·David Cédric LaufferAbdelkarim Said Allal
Dec 5, 2018·International Journal of Surgical Pathology·Francesca SanguedolceLuigi Cormio

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